Gonadotropin-releasing hormone

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GNRH1
Identifiers
Aliases	GNRH1, GNRH, GRH, HH12, LHRH, LNRH, gonadotropin releasing hormone 1, Gonadotropin-Releasing Hormone
External IDs	OMIM: 152760; MGI: 95789; HomoloGene: 641; GeneCards: GNRH1; OMA:GNRH1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.2 Start 25,419,258 bp[1] End 25,424,654 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D1 Start 67,982,630 bp[2] End 67,986,888 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibial nerve testicle cerebellar hemisphere putamen ascending aorta Descending thoracic aorta mucosa of transverse colon right hemisphere of cerebellum popliteal artery tibial arteries Top expressed in primary oocyte bone marrow embryonic cell zygote secondary oocyte morula neural layer of retina granulocyte thymus preoptic area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hormone activity gonadotropin hormone-releasing hormone activity gonadotropin-releasing hormone receptor binding Cellular component axon terminus perikaryon Golgi-associated vesicle extracellular region neurosecretory vesicle dendrite mitochondrion neuron projection cytoplasmic side of rough endoplasmic reticulum membrane extracellular space Biological process negative regulation of immature T cell proliferation response to prolactin negative regulation of neuron migration response to potassium ion response to organic cyclic compound response to testosterone estrous cycle female pregnancy cell-cell signaling response to steroid hormone human ageing response to peptide hormone negative regulation of apoptotic process male sex determination multicellular organism development response to prostaglandin E response to lipopolysaccharide response to corticosteroid regulation of gene expression ovulation cycle response to ethanol regulation of ovarian follicle development signal transduction negative regulation of cell population proliferation regulation of signaling receptor activity G protein-coupled receptor signaling pathway reproduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2796 14714 Ensembl ENSG00000147437 ENSMUSG00000015812 UniProt P01148 P13562 RefSeq (mRNA) NM_001083111 NM_000825 NM_008145 RefSeq (protein) NP_000816 NP_001076580 NP_032171 Location (UCSC) Chr 8: 25.42 – 25.42 Mb Chr 14: 67.98 – 67.99 Mb PubMed search [3] [4]
Wikidata
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Gonadotropin-releasing hormone (GnRH) is a releasing hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is a tropic peptide hormone synthesized and released from GnRH neurons within the hypothalamus. The peptide belongs to gonadotropin-releasing hormone family. It constitutes the initial step in the hypothalamic–pituitary–gonadal axis.^{[citation needed]}