Gonadotropin-releasing hormone receptor

Gonadotropin-releasing hormone receptor
Identifiers
SymbolGNRHR
Alt. symbolsGnRH-R; LRHR;
NCBI gene2798
HGNC4421
OMIM138850
RefSeqNM_000406
UniProtP30968
Other data
LocusChr. 4 q21.2
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StructuresSwiss-model
DomainsInterPro
Gonadotropin-releasing hormone (type 2) receptor 2
Identifiers
SymbolGNRHR2
NCBI gene114814
HGNC16341
RefSeqNR_002328
UniProtQ96P88
Other data
LocusChr. 1 q12
Search for
StructuresSwiss-model
DomainsInterPro

The gonadotropin-releasing hormone receptor (GnRHR), also known as the luteinizing hormone releasing hormone receptor (LHRHR), is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is the receptor of gonadotropin-releasing hormone (GnRH). Agonist binding to the GnRH receptor activates the Gq/11 family of heterotrimeric G proteins.[1] The GnRHR is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate.

This receptor is a 60 kDa G protein-coupled receptor and resides primarily in the pituitary and is responsible for eliciting the actions of GnRH after its release from the hypothalamus.[2] Upon activation, the LHRHr stimulates tyrosine phosphatase and elicits the release of LH from the pituitary.

Evidence exists showing the presence of GnRH and its receptor in extrapituitary tissues as well as a role in progression of some cancers.[3]

  1. ^ Flanagan, Colleen A.; Manilall, Ashmeetha (2017). "Gonadotropin-releasing hormone (GnRH) receptor structure and GnRH binding". Frontiers in Endocrinology. 8: 274. doi:10.3389/fendo.2017.00274. PMC 5662886. PMID 29123501.
  2. ^ Millar RP (2005). "GnRHs and GnRH receptors". Anim. Reprod. Sci. 88 (1–2): 5–28. doi:10.1016/j.anireprosci.2005.05.032. PMID 16140177.
  3. ^ Harrison GS, Wierman ME, Nett TM, Glode LM (2004). "Gonadotropin-releasing hormone and its receptor in normal and malignant cells". Endocr. Relat. Cancer. 11 (4): 725–48. doi:10.1677/erc.1.00777. PMID 15613448.