| Granulin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 The solution structure of a well-folded peptide based on the 31-residue amino-terminal subdomain of human granulin a | |||||||||
| Identifiers | |||||||||
| Symbol | Granulin | ||||||||
| Pfam | PF00396 | ||||||||
| InterPro | IPR000118 | ||||||||
| PROSITE | PDOC00634 | ||||||||
| SCOP2 | 1pcn / SCOPe / SUPFAM | ||||||||
| |||||||||
Granulin is a protein that in humans is encoded by the GRN gene.[5][6][7] Each granulin protein is cleaved from the precursor progranulin, a 593 amino-acid-long and 68.5 kDa protein.[8] While the function of progranulin and granulin have yet to be determined, both forms of the protein have been implicated in development, inflammation, cell proliferation and protein homeostasis. The 2006 discovery of the GRN mutation in a population of patients with frontotemporal dementia has spurred much research in uncovering the function and involvement in disease of progranulin in the body. While there is a growing body of research on progranulin's role in the body, studies on specific granulin residues are still limited.
- ^ a b c GRCh38: Ensembl release 89: ENSG00000030582 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034708 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Bhandari V, Bateman A (October 1992). "Structure and chromosomal location of the human granulin gene". Biochemical and Biophysical Research Communications. 188 (1): 57–63. doi:10.1016/0006-291X(92)92349-3. PMID 1417868.
- ^ Zhang H, Serrero G (November 1998). "Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor)". Proceedings of the National Academy of Sciences of the United States of America. 95 (24): 14202–14207. Bibcode:1998PNAS...9514202Z. doi:10.1073/pnas.95.24.14202. PMC 24351. PMID 9826678.
- ^ "Entrez Gene: GRN granulin".
- ^ Eriksen JL, Mackenzie IR (January 2008). "Progranulin: normal function and role in neurodegeneration". Journal of Neurochemistry. 104 (2): 287–297. doi:10.1111/j.1471-4159.2007.04968.x. PMID 17953663. S2CID 43261477.