Granulocyte-macrophage colony-stimulating factor

CSF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CSG, 2GMF, 4NKQ, 5C7X, 5D70, 5D71, 5D72, 4RS1
Identifiers
Aliases	CSF2, GMCSF, colony stimulating factor 2, CSF
External IDs	OMIM: 138960; MGI: 1339752; HomoloGene: 600; GeneCards: CSF2; OMA:CSF2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.1 Start 132,073,789 bp[1] End 132,076,170 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B1.3|11 32.13 cM Start 54,138,097 bp[2] End 54,140,493 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue upper lobe of left lung gallbladder stromal cell of endometrium appendix islet of Langerhans muscle tissue smooth muscle tissue granulocyte rectum Top expressed in left lung lobe right lung lobe jejunum duodenum piriform cortex artery haematopoietic system thymus colon carotid body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function growth factor activity granulocyte macrophage colony-stimulating factor receptor binding protein binding protein tyrosine kinase activity cytokine activity Cellular component extracellular region intracellular membrane-bounded organelle extracellular space Biological process negative regulation of cytolysis positive regulation of macrophage derived foam cell differentiation regulation of cell population proliferation MAPK cascade positive regulation of podosome assembly negative regulation of extrinsic apoptotic signaling pathway in absence of ligand positive regulation of interleukin-23 production positive regulation of gene expression embryonic placenta development epithelial fluid transport regulation of gene expression dendritic cell differentiation myeloid dendritic cell differentiation macrophage activation cellular response to lipopolysaccharide immune response monocyte differentiation response to fluid shear stress response to silicon dioxide neutrophil differentiation peptidyl-tyrosine phosphorylation regulation of circadian sleep/wake cycle, sleep histamine secretion positive regulation of tyrosine phosphorylation of STAT protein cellular response to granulocyte macrophage colony-stimulating factor stimulus regulation of myeloid cell differentiation regulation of signaling receptor activity negative regulation of transcription, DNA-templated cytokine-mediated signaling pathway positive regulation of cell population proliferation macrophage differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1437 12981 Ensembl ENSG00000164400 ENSMUSG00000018916 UniProt P04141 P01587 RefSeq (mRNA) NM_000758 NM_009969 RefSeq (protein) NP_000749 NP_034099 Location (UCSC) Chr 5: 132.07 – 132.08 Mb Chr 11: 54.14 – 54.14 Mb PubMed search [3] [4]
Wikidata
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Granulocyte-macrophage colony-stimulating factor
three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM_CSF)
Identifiers
Symbol	GM_CSF
Pfam	PF01109
Pfam clan	CL0053
InterPro	IPR000773
PROSITE	PDOC00584
SCOP2	2gmf / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Granulocyte-macrophage colony-stimulating factor

Clinical data
ATC code	L03AA09 (WHO)
Identifiers
IUPAC name Human granulocyte macrophage colony stimulating factor
CAS Number	83869-56-1 Y
DrugBank	DB00020 N
ChemSpider	none
Chemical and physical data
Formula	C639H1006N168O196S8
Molar mass	14434.54 g·mol−1
NY (what is this?)  (verify)

Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called sargramostim and molgramostim.

Unlike granulocyte colony-stimulating factor, which specifically promotes neutrophil proliferation and maturation, GM-CSF affects more cell types, especially macrophages and eosinophils.^[5]