Growth hormone receptor

GHR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A22, 1AXI, 1HWG, 1HWH, 1KF9, 2AEW, 3HHR
Identifiers
Aliases	GHR, GHBP, GHIP, growth hormone receptor
External IDs	OMIM: 600946; MGI: 95708; HomoloGene: 134; GeneCards: GHR; OMA:GHR - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	42,721,878 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	3,612,974 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii; ; deltoid muscle; ; vastus lateralis muscle; ; liver; ; Achilles tendon; ; tibialis anterior muscle; ; glutes; ; triceps brachii muscle; ; adipose tissue;
	Top expressed in
	proximal tubule; ; white adipose tissue; ; right kidney; ; left lobe of liver; ; human kidney; ; intercostal muscle; ; tunica adventitia of aorta; ; subcutaneous adipose tissue; ; ankle; ; sternocleidomastoid muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; growth factor binding; peptide hormone binding; protein binding; cytokine receptor activity; proline-rich region binding; protein kinase binding; identical protein binding; growth hormone receptor activity; cytokine binding;
Cellular component	integral component of membrane; membrane; receptor complex; integral component of plasma membrane; extracellular region; cell surface; growth hormone receptor complex; extracellular space; cytosol; plasma membrane; cytoplasmic ribonucleoprotein granule; external side of plasma membrane;
Biological process	insulin-like growth factor receptor signaling pathway; receptor signaling pathway via JAK-STAT; growth hormone receptor signaling pathway via JAK-STAT; response to estradiol; endocytosis; allantoin metabolic process; regulation of multicellular organism growth; cytokine-mediated signaling pathway; citrate metabolic process; receptor internalization; response to cycloheximide; 2-oxoglutarate metabolic process; creatinine metabolic process; oxaloacetate metabolic process; fatty acid metabolic process; succinate metabolic process; cellular response to hormone stimulus; growth hormone receptor signaling pathway; taurine metabolic process; valine metabolic process; positive regulation of multicellular organism growth; positive regulation of peptidyl-tyrosine phosphorylation; creatine metabolic process; isoleucine metabolic process; positive regulation of tyrosine phosphorylation of STAT protein; activation of Janus kinase activity; hormone metabolic process; positive regulation of receptor signaling pathway via JAK-STAT;
	Sources:Amigo / QuickGO
Orthologs
	2690
	14600
	ENSG00000112964
	ENSMUSG00000055737
	P10912
	P16882
NM_000163; NM_001242399; NM_001242400; NM_001242401; NM_001242402;
	NM_001242403; NM_001242404; NM_001242405; NM_001242406; NM_001242460; NM_001242461; NM_001242462
	NM_001048147; NM_001048178; NM_010284; NM_001286370
NP_000154; NP_001229328; NP_001229329; NP_001229330; NP_001229331;
	NP_001229332; NP_001229333; NP_001229334; NP_001229335; NP_001229389; NP_001229391
	NP_001041643; NP_001273299; NP_034414
	Wikidata
View/Edit Human	View/Edit Mouse

Growth hormone receptor is a protein that in humans is encoded by the GHR gene.^[5] GHR orthologs^[6] have been identified in most mammals.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112964 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055737 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GHR growth hormone receptor".
^ "OrthoMaM phylogenetic marker: GHR coding sequence". Archived from the original on 2015-09-24. Retrieved 2009-11-18.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112964 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055737 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GHR growth hormone receptor".

[OrthoMaM-6] "OrthoMaM phylogenetic marker: GHR coding sequence". Archived from the original on 2015-09-24. Retrieved 2009-11-18.

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