Grubbs catalyst

Grubbs catalysts are a series of transition metal carbene complexes used as catalysts for olefin metathesis. They are named after Robert H. Grubbs, the chemist who supervised their synthesis. Several generations of the catalyst have also been developed.[1][2] Grubbs catalysts tolerate many functional groups in the alkene substrates, are air-tolerant, and are compatible with a wide range of solvents.[3][4] For these reasons, Grubbs catalysts have become popular in synthetic organic chemistry.[5] Grubbs, together with Richard R. Schrock and Yves Chauvin, won the Nobel Prize in Chemistry in recognition of their contributions to the development of olefin metathesis.

  1. ^ Grubbs, Robert H. (2003). Handbook of Metathesis (1st ed.). Weinheim: Wiley-VCH. ISBN 978-3-527-30616-9.
  2. ^ Grubbs, R. H.; Trnka, T. M. (2004). "Ruthenium-Catalyzed Olefin Metathesis". In Murahashi, S. (ed.). Ruthenium in Organic Synthesis. Weinheim: Wiley-VCH. pp. 153–177. doi:10.1002/3527603832.ch6. ISBN 978-3-527-60383-1.
  3. ^ Vougioukalakis, G. C.; Grubbs, R. H. (2010). "Ruthenium-Based Heterocyclic Carbene-Coordinated Olefin Metathesis Catalysts". Chemical Reviews. 110 (3): 1746–1787. doi:10.1021/cr9002424. PMID 20000700.
  4. ^ Trnka, T. M.; Grubbs, R. H. (2001). "The Development of L2X2Ru=CHR Olefin Metathesis Catalysts: An Organometallic Success Story". Accounts of Chemical Research. 34 (1): 18–29. doi:10.1021/ar000114f. PMID 11170353.
  5. ^ Cossy, Janine; Arseniyadis, Stellios; Meyer, Christophe (2010). Metathesis in Natural Product Synthesis: Strategies, Substrates and Catalysts (1st ed.). Weinheim: Wiley-VCH. ISBN 978-3-527-32440-8.