Guanabenz

Guanabenz
Clinical data
Trade names	Wytensin
AHFS/Drugs.com	Consumer Drug Information
MedlinePlus	a686003
ATC code	none;
Pharmacokinetic data
Protein binding	90%
Elimination half-life	6 hours
Identifiers
	IUPAC name 2-(2,6-dichlorobenzylidene)hydrazinecarboximidamide;
CAS Number	5051-62-7;
PubChem CID	5702063;
IUPHAR/BPS	5443;
DrugBank	DB00629 ;
ChemSpider	4642445 ;
UNII	GGD30112WC;
KEGG	D04375 ;
ChEMBL	ChEMBL420 ;
CompTox Dashboard (EPA)	DTXSID6045666 ;
ECHA InfoCard	100.023.410
Chemical and physical data
Formula	C8H8Cl2N4
Molar mass	231.08 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1cccc(Cl)c1\C=N\N=C(/N)N;
	InChI InChI=1S/C8H8Cl2N4/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12/h1-4H,(H4,11,12,14)/b13-4+ ; Key:WDZVGELJXXEGPV-YIXHJXPBSA-N ;
	(verify)

Guanabenz (pronounced GWAHN-a-benz, sold under the trade name Wytensin) is an alpha agonist that is selective to the alpha-2 adrenergic receptor. Guanabenz is used as an antihypertensive drug used in the treatment of high blood pressure (hypertension).^[1]^[2]

The most common side effects during guanabenz therapy are dizziness, drowsiness, dry mouth, headache and weakness.^[3]

Guanabenz can make one drowsy or less alert, therefore driving or operating dangerous machinery is not recommended.

^ Walker BR, Hare LE, Deitch MW (1982). "Comparative antihypertensive effects of guanabenz and clonidine". The Journal of International Medical Research. 10 (1): 6–14. doi:10.1177/030006058201000102. PMID 7037502. S2CID 2139809.^{[permanent dead link]}
^ Bonham AC, Trapani AJ, Portis LR, Brody MJ (December 1984). "Studies on the mechanism of the central antihypertensive effect of guanabenz and clonidine". Journal of Hypertension Supplement. 2 (3): S543–S546. PMID 6599714.^{[permanent dead link]}
^ "Guanabenz | The Merck Index Online". www.rsc.org. Retrieved 2023-04-17.