H2AFX

H2AX
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D31, 2DYP, 3SHV, 3SQD, 3SZM, 1YDP, 2AZM, 3U3Z
Identifiers
Aliases	H2AX, H2A.X, H2A/X, H2A histone family member X, H2A.X variant histone, H2AFX
External IDs	OMIM: 601772; MGI: 102688; HomoloGene: 134201; GeneCards: H2AX; OMA:H2AX - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 119,093,874 bp[1] End 119,095,465 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.2|9 24.84 cM Start 44,245,991 bp[2] End 44,247,374 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone embryo ganglionic eminence mucosa of transverse colon oocyte inferior ganglion of vagus nerve thymus trabecular bone C1 segment subthalamic nucleus Top expressed in medial ganglionic eminence abdominal wall maxillary prominence mandibular prominence tail of embryo tibiofemoral joint genital tubercle epiblast somite ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding histone binding protein binding protein heterodimerization activity enzyme binding damaged DNA binding Cellular component nucleoplasm chromosome telomere nucleosome extracellular exosome nuclear speck centrosome nucleus site of double-strand break chromatin condensed nuclear chromosome male germ cell nucleus XY body replication fork site of DNA damage Biological process response to ionizing radiation nucleosome assembly DNA recombination DNA damage checkpoint signaling positive regulation of DNA repair cellular response to DNA damage stimulus cellular senescence meiosis cellular response to gamma radiation spermatogenesis cerebral cortex development cell cycle viral process double-strand break repair via nonhomologous end joining double-strand break repair DNA repair double-strand break repair via homologous recombination chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3014 15270 Ensembl ENSG00000188486 ENSMUSG00000049932 UniProt P16104 P27661 RefSeq (mRNA) NM_002105 NM_010436 RefSeq (protein) NP_002096 NP_034566 Location (UCSC) Chr 11: 119.09 – 119.1 Mb Chr 9: 44.25 – 44.25 Mb PubMed search [3] [4]
Wikidata
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H2A histone family member X (usually abbreviated as H2AX) is a type of histone protein from the H2A family encoded by the H2AFX gene. An important phosphorylated form is γH2AX (S139), which forms when double-strand breaks appear.

In humans and other eukaryotes, the DNA is wrapped around histone octamers, consisting of core histones H2A, H2B, H3 and H4, to form chromatin. H2AX contributes to nucleosome-formation, chromatin-remodeling and DNA repair, and is also used in vitro as an assay for double-strand breaks in dsDNA.