HAGH

HAGH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1QH3, 1QH5
Identifiers
Aliases	HAGH, GLO2, GLX2, GLXII, HAGH1, hydroxyacylglutathione hydrolase
External IDs	OMIM: 138760; MGI: 95745; HomoloGene: 3890; GeneCards: HAGH; OMA:HAGH - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	1,827,157 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	25,083,424 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right lobe of liver; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; gastrocnemius muscle; ; left adrenal cortex; ; prefrontal cortex; ; muscle of thigh; ; left testis;
	Top expressed in
	spermatid; ; right kidney; ; spermatocyte; ; left lobe of liver; ; blood; ; proximal tubule; ; seminiferous tubule; ; human kidney; ; facial motor nucleus; ; tibiofemoral joint;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hydroxyacylglutathione hydrolase activity; protein binding; hydrolase activity; metal ion binding;
Cellular component	cytoplasm; cytosol; mitochondrial matrix; mitochondrion;
Biological process	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; glutathione biosynthetic process; pyruvate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	3029
	14651
	ENSG00000063854
	ENSMUSG00000024158
	Q16775
	Q99KB8
	NM_001040427; NM_001286249; NM_005326; NM_001363912; NM_001363914
	NM_001159626; NM_024284
	NP_001035517; NP_001273178; NP_005317; NP_001350841; NP_001350843
	NP_001153098; NP_077246
	Wikidata
View/Edit Human	View/Edit Mouse

Hydroxyacylglutathione hydrolase, mitochondrial is an enzyme that in humans is encoded by the HAGH gene.^[5]^[6]^[7]

The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000063854 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024158 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mulley JC, Callen DF (Feb 1987). "New regional localisations for HAGH and PGP on human chromosome 16". Hum Genet. 74 (4): 423–4. doi:10.1007/BF00280498. PMID 3025077. S2CID 19620852.
^ Honey NK, Shows TB (Apr 1982). "Assignment of the glyoxalase II gene (HAGH) to human chromosome 16". Hum Genet. 58 (4): 358–61. doi:10.1007/bf00282815. PMID 7327557. S2CID 10452468.
^ ^a ^b "Entrez Gene: HAGH hydroxyacylglutathione hydrolase".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000063854 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024158 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3025077-5] Mulley JC, Callen DF (Feb 1987). "New regional localisations for HAGH and PGP on human chromosome 16". Hum Genet. 74 (4): 423–4. doi:10.1007/BF00280498. PMID 3025077. S2CID 19620852.

[pmid7327557-6] Honey NK, Shows TB (Apr 1982). "Assignment of the glyoxalase II gene (HAGH) to human chromosome 16". Hum Genet. 58 (4): 358–61. doi:10.1007/bf00282815. PMID 7327557. S2CID 10452468.

[entrez-7] "Entrez Gene: HAGH hydroxyacylglutathione hydrolase".

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