HAND2

HAND2
Identifiers
Aliases	HAND2, DHed, Thing2, bHLHa26, dHand, heart and neural crest derivatives expressed 2
External IDs	OMIM: 602407; MGI: 103580; HomoloGene: 32092; GeneCards: HAND2; OMA:HAND2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	173,530,229 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	57,777,668 bp
RNA expression pattern
	Top expressed in
	muscle layer of sigmoid colon; ; apex of heart; ; body of uterus; ; right auricle; ; canal of the cervix; ; ascending aorta; ; Descending thoracic aorta; ; left ventricle; ; left coronary artery; ; stromal cell of endometrium;
	Top expressed in
	gastrula; ; decidua; ; endocardial cushion; ; abdominal wall; ; external carotid artery; ; mandibular prominence; ; internal carotid artery; ; atrioventricular valve; ; bulbus cordis; ; atrium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; protein homodimerization activity; protein dimerization activity; minor groove of adenine-thymine-rich DNA binding; transcription coactivator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; E-box binding; protein binding; protein heterodimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	transcription regulator complex; nucleus; protein-containing complex;
Biological process	positive regulation of transcription regulatory region DNA binding; peripheral nervous system neuron development; roof of mouth development; apoptotic process involved in heart morphogenesis; noradrenergic neuron differentiation; cell differentiation; mesenchymal cell proliferation; determination of heart left/right asymmetry; regulation of transcription, DNA-templated; sympathetic nervous system development; tongue development; neural crest cell development; cell proliferation involved in outflow tract morphogenesis; adult heart development; cardiac right ventricle formation; thymus development; mesenchyme development; cardiac neural crest cell migration involved in outflow tract morphogenesis; negative regulation of DNA binding; coronary artery morphogenesis; embryonic digit morphogenesis; positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process; visceral serous pericardium development; heart morphogenesis; negative regulation of apoptotic process; in utero embryonic development; negative regulation of DNA-binding transcription factor activity; negative regulation of osteoblast differentiation; transcription, DNA-templated; cardiac neural crest cell development involved in outflow tract morphogenesis; positive regulation of transcription, DNA-templated; heart looping; odontogenesis of dentin-containing tooth; positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis; multicellular organism development; negative regulation of cardiac muscle cell apoptotic process; heart development; regulation of secondary heart field cardioblast proliferation; angiogenesis; cartilage morphogenesis; positive regulation of transcription by RNA polymerase II; suckling behavior; regulation of tissue remodeling; negative regulation of gene expression; positive regulation of ERK1 and ERK2 cascade; positive regulation of p38MAPK cascade; positive regulation of cardiac muscle hypertrophy; positive regulation of gene expression; transcription by RNA polymerase II; primary palate development;
	Sources:Amigo / QuickGO
Orthologs
	9464
	15111
	ENSG00000164107
	ENSMUSG00000038193
	P61296
	Q61039
	NM_021973
	NM_010402
	NP_068808
	NP_034532
	Wikidata
View/Edit Human	View/Edit Mouse

Heart- and neural crest derivatives-expressed protein 2 is a protein that in humans is encoded by the HAND2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164107 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038193 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Russell MW, Kemp P, Wang L, Brody LC, Izumo S (December 1998). "Molecular cloning of the human HAND2 gene". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1443 (3): 393–9. doi:10.1016/S0167-4781(98)00237-1. PMID 9878849.
^ "Entrez Gene: HAND2 heart and neural crest derivatives expressed 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164107 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038193 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9878849-5] Russell MW, Kemp P, Wang L, Brody LC, Izumo S (December 1998). "Molecular cloning of the human HAND2 gene". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1443 (3): 393–9. doi:10.1016/S0167-4781(98)00237-1. PMID 9878849.

[entrez-6] "Entrez Gene: HAND2 heart and neural crest derivatives expressed 2".

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