HAVCR1

HAVCR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5DZO, 5F70
Identifiers
Aliases	HAVCR1, HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1, CD365, hepatitis A virus cellular receptor 1
External IDs	OMIM: 606518; MGI: 2159680; HomoloGene: 134424; GeneCards: HAVCR1; OMA:HAVCR1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	157,059,119 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	46,670,405 bp
RNA expression pattern
	Top expressed in
	testicle; ; human kidney; ; rectum; ; gonad; ; granulocyte; ; epithelium of colon; ; lymph node; ; blood; ; endometrium; ; islet of Langerhans;
	Top expressed in
	blastocyst; ; zygote; ; decidua; ; morula; ; secondary oocyte; ; mesenteric lymph nodes; ; embryo; ; primary oocyte; ; proximal tubule; ; spleen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	virus receptor activity;
Cellular component	integral component of membrane; motile cilium; membrane;
Biological process	viral process; viral entry into host cell;
	Sources:Amigo / QuickGO
Orthologs
	26762
	171283
	ENSG00000113249
	ENSMUSG00000040405
	Q96D42
	Q5QNS5
	NM_001099414; NM_001173393; NM_001308156; NM_012206
	NM_001166631; NM_001166632; NM_134248
	NP_001166864; NP_001295085; NP_036338
	NP_001160103; NP_001160104; NP_599009
	Wikidata
View/Edit Human	View/Edit Mouse

Hepatitis A virus cellular receptor 1 (HAVcr-1) also known as T-cell immunoglobulin and mucin domain 1 (TIM-1) is a protein that in humans is encoded by the HAVCR1 gene.^[5]^[6]^[7]

It is also known as KIM-1 Kidney Injury Molecule -1, which is a type 1 transmembrane protein the most highly upregulated in injured kidneys by various types of insults.^[8] Its upregulation during renal injury has been found in the kidneys of the vertebrates such as Zebrafish and humans.

The hepatitis A virus cellular receptor 1 (HAVCR1/TIM-1), is a member of the TIM (T cell transmembrane, immunoglobulin, and mucin) gene family, which plays critical roles in regulating immune cell activity especially regarding the host response to viral infection. TIM-1 is also involved in allergic response, asthma, and transplant tolerance.

The TIM gene family was first cloned from the mouse model of asthma in 2001.^[6] Subsequently, it was demonstrated that members of the TIM gene family including TIM-1 participate in host immune response. The mouse TIM gene family contains eight members (TIM-1-8) while only three TIM genes (TIM-1, TIM-3, and TIM-4) have been identified in humans.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113249 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040405 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Feigelstock D, Thompson P, Mattoo P, Zhang Y, Kaplan GG (Aug 1998). "The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor". Journal of Virology. 72 (8): 6621–6628. doi:10.1128/JVI.72.8.6621-6628.1998. PMC 109848. PMID 9658108.
^ ^a ^b McIntire JJ, Umetsu SE, Akbari O, Potter M, Kuchroo VK, Barsh GS, Freeman GJ, Umetsu DT, DeKruyff RH (November 2001). "Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family". Nature Immunology. 2 (12): 1109–1116. doi:10.1038/ni739. PMID 11725301. S2CID 7243788.
^ "Entrez Gene: HAVCR1 hepatitis A virus cellular receptor 1".
^ Han WK, Bailly V, Abichandani R, Thadhani R, Bonventre JV (July 2002). "Kidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury". Kidney International. 62 (1): 237–244. doi:10.1046/j.1523-1755.2002.00433.x. ISSN 0085-2538. PMID 12081583.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113249 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040405 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9658108-5] Feigelstock D, Thompson P, Mattoo P, Zhang Y, Kaplan GG (Aug 1998). "The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor". Journal of Virology. 72 (8): 6621–6628. doi:10.1128/JVI.72.8.6621-6628.1998. PMC 109848. PMID 9658108.

[pmid11725301-6] McIntire JJ, Umetsu SE, Akbari O, Potter M, Kuchroo VK, Barsh GS, Freeman GJ, Umetsu DT, DeKruyff RH (November 2001). "Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family". Nature Immunology. 2 (12): 1109–1116. doi:10.1038/ni739. PMID 11725301. S2CID 7243788.

[entrez-7] "Entrez Gene: HAVCR1 hepatitis A virus cellular receptor 1".

[8] Han WK, Bailly V, Abichandani R, Thadhani R, Bonventre JV (July 2002). "Kidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury". Kidney International. 62 (1): 237–244. doi:10.1046/j.1523-1755.2002.00433.x. ISSN 0085-2538. PMID 12081583.

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