HCN1

HCN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3U0Z
Identifiers
Aliases	HCN1, BCNG-1, BCNG1, EIEE24, HAC-2, hyperpolarization activated cyclic nucleotide gated potassium channel 1, GEFSP10, DEE24
External IDs	OMIM: 602780; MGI: 1096392; HomoloGene: 32093; GeneCards: HCN1; OMA:HCN1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	45,696,498 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	118,123,954 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; primary visual cortex; ; trigeminal ganglion; ; Brodmann area 46; ; spinal ganglia; ; prefrontal cortex; ; superior frontal gyrus; ; middle temporal gyrus; ; parietal lobe;
	Top expressed in
	subiculum; ; medial vestibular nucleus; ; pontine nuclei; ; deep cerebellar nuclei; ; cerebellar vermis; ; facial motor nucleus; ; lobe of cerebellum; ; lumbar spinal ganglion; ; anterior horn of spinal cord; ; inferior colliculi;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; intracellular cAMP-activated cation channel activity; identical protein binding; voltage-gated sodium channel activity; ion channel activity; potassium channel activity; sodium channel activity; voltage-gated ion channel activity; voltage-gated potassium channel activity; voltage-gated cation channel activity; cAMP binding; protein binding;
Cellular component	axon; membrane; dendrite; plasma membrane; integral component of membrane; HCN channel complex; integral component of plasma membrane;
Biological process	transmembrane transport; retinal cone cell development; regulation of ion transmembrane transport; apical protein localization; ion transport; sodium ion transport; regulation of membrane potential; sodium ion transmembrane transport; potassium ion transmembrane transport; potassium ion transport; protein homotetramerization; cellular response to cAMP;
	Sources:Amigo / QuickGO
Orthologs
	348980
	15165
	ENSG00000164588
	ENSMUSG00000021730
	O60741
	O88704
	NM_021072
	NM_010408
	NP_066550
	NP_034538
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 is a protein that in humans is encoded by the HCN1 gene.^[5]^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164588 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021730 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Santoro B, Grant SG, Bartsch D, Kandel ER (December 1997). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proceedings of the National Academy of Sciences of the United States of America. 94 (26): 14815–14820. Bibcode:1997PNAS...9414815S. doi:10.1073/pnas.94.26.14815. PMC 25120. PMID 9405696.
^ Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR (May 1998). "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain". Cell. 93 (5): 717–729. doi:10.1016/S0092-8674(00)81434-8. PMID 9630217.
^ Hofmann F, Biel M, Kaupp UB (December 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacological Reviews. 57 (4): 455–462. doi:10.1124/pr.57.4.8. PMID 16382102. S2CID 45853869.
^ "Entrez Gene: HCN1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164588 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021730 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9405696-5] Santoro B, Grant SG, Bartsch D, Kandel ER (December 1997). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proceedings of the National Academy of Sciences of the United States of America. 94 (26): 14815–14820. Bibcode:1997PNAS...9414815S. doi:10.1073/pnas.94.26.14815. PMC 25120. PMID 9405696.

[pmid9630217-6] Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR (May 1998). "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain". Cell. 93 (5): 717–729. doi:10.1016/S0092-8674(00)81434-8. PMID 9630217.

[pmid16382102-7] Hofmann F, Biel M, Kaupp UB (December 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacological Reviews. 57 (4): 455–462. doi:10.1124/pr.57.4.8. PMID 16382102. S2CID 45853869.

[entrez-8] "Entrez Gene: HCN1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1".

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