HCN2

HCN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MPF, 3U10
Identifiers
Aliases	HCN2, BCNG-2, BCNG2, HAC-1, hyperpolarization activated cyclic nucleotide gated potassium channel 2, hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2, EIG17, FEB2, GEFSP11
External IDs	OMIM: 602781; MGI: 1298210; HomoloGene: 31022; GeneCards: HCN2; OMA:HCN2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	617,159 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,571,942 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; right frontal lobe; ; putamen; ; nucleus accumbens; ; anterior cingulate cortex; ; caudate nucleus; ; Brodmann area 10; ; Brodmann area 9; ; amygdala; ; right hemisphere of cerebellum;
	Top expressed in
	perirhinal cortex; ; entorhinal cortex; ; primary visual cortex; ; superior frontal gyrus; ; CA3 field; ; choroid plexus of fourth ventricle; ; central gray substance of midbrain; ; cerebellar cortex; ; medulla oblongata; ; lumbar subsegment of spinal cord;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; potassium channel activity; cAMP binding; sodium channel activity; voltage-gated ion channel activity; ion channel activity; intracellular cAMP-activated cation channel activity; identical protein binding; voltage-gated potassium channel activity; voltage-gated sodium channel activity; protein binding;
Cellular component	integral component of membrane; membrane; voltage-gated potassium channel complex; plasma membrane; integral component of plasma membrane; HCN channel complex;
Biological process	cellular response to cGMP; sodium ion transmembrane transport; sodium ion transport; cell-cell signaling; regulation of membrane potential; regulation of ion transmembrane transport; ion transport; potassium ion transport; transmembrane transport; potassium ion transmembrane transport; cellular response to cAMP; membrane depolarization during cardiac muscle cell action potential; sodium ion import across plasma membrane; potassium ion import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	610
	15166
	ENSG00000099822
	ENSMUSG00000020331
	Q9UL51
	O88703
	NM_001194
	NM_008226
	NP_001185
	NP_032252
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 is a protein that in humans is encoded by the HCN2 gene.^[5]^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000099822 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020331 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Santoro B, Grant SG, Bartsch D, Kandel ER (Dec 1997). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proceedings of the National Academy of Sciences of the United States of America. 94 (26): 14815–20. Bibcode:1997PNAS...9414815S. doi:10.1073/pnas.94.26.14815. PMC 25120. PMID 9405696.
^ Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR (May 1998). "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain". Cell. 93 (5): 717–29. doi:10.1016/S0092-8674(00)81434-8. PMID 9630217. S2CID 10265917.
^ Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacological Reviews. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102. S2CID 45853869.
^ "Entrez Gene: HCN2 hyperpolarization activated cyclic nucleotide-gated potassium channel 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099822 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020331 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9405696-5] Santoro B, Grant SG, Bartsch D, Kandel ER (Dec 1997). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proceedings of the National Academy of Sciences of the United States of America. 94 (26): 14815–20. Bibcode:1997PNAS...9414815S. doi:10.1073/pnas.94.26.14815. PMC 25120. PMID 9405696.

[pmid9630217-6] Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR (May 1998). "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain". Cell. 93 (5): 717–29. doi:10.1016/S0092-8674(00)81434-8. PMID 9630217. S2CID 10265917.

[pmid16382102-7] Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacological Reviews. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102. S2CID 45853869.

[entrez-8] "Entrez Gene: HCN2 hyperpolarization activated cyclic nucleotide-gated potassium channel 2".

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