HCN3

HCN3
Identifiers
Aliases	HCN3, hyperpolarization activated cyclic nucleotide gated potassium channel 3
External IDs	OMIM: 609973; MGI: 1298211; HomoloGene: 22453; GeneCards: HCN3; OMA:HCN3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	155,289,848 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	89,067,503 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; testicle; ; ganglionic eminence; ; mucosa of transverse colon; ; ventricular zone; ; pituitary gland; ; anterior pituitary; ; hypothalamus; ; superior frontal gyrus; ; right frontal lobe;
	Top expressed in
	neural layer of retina; ; perirhinal cortex; ; entorhinal cortex; ; pineal gland; ; barrel cortex; ; CA3 field; ; spinal ganglia; ; glossopharyngeal ganglion; ; olfactory bulb; ; choroid plexus of fourth ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; potassium channel activity; cAMP binding; sodium channel activity; voltage-gated ion channel activity; ion channel activity; voltage-gated potassium channel activity; voltage-gated sodium channel activity; protein binding;
Cellular component	integral component of membrane; membrane; plasma membrane; synapse; soma; axon; dendrite; cone cell pedicle; integral component of plasma membrane;
Biological process	sodium ion transmembrane transport; sodium ion transport; cellular response to dopamine; regulation of membrane potential; regulation of ion transmembrane transport; ion transport; potassium ion transport; response to cisplatin; transmembrane transport; potassium ion transmembrane transport; cellular response to cAMP;
	Sources:Amigo / QuickGO
Orthologs
	57657
	15168
	ENSG00000143630; ENSG00000263324
	ENSMUSG00000028051
	Q9P1Z3
	O88705
	NM_020897
	NM_008227
	NP_065948
	NP_032253
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 is a protein that in humans is encoded by the HCN3 gene.^[5]^[6]

^ ^a ^b ^c ENSG00000263324 GRCh38: Ensembl release 89: ENSG00000143630, ENSG00000263324 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028051 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102. S2CID 45853869.
^ "Entrez Gene: HCN3 hyperpolarization activated cyclic nucleotide-gated potassium channel 3".

[refGRCh38Ensembl-1] ENSG00000263324 GRCh38: Ensembl release 89: ENSG00000143630, ENSG00000263324 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028051 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16382102-5] Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102. S2CID 45853869.

[entrez-6] "Entrez Gene: HCN3 hyperpolarization activated cyclic nucleotide-gated potassium channel 3".

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