HDAC1

HDAC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BKX, 5ICN
Identifiers
Aliases	HDAC1, GON-10, HD1, RPD3, RPD3L1, histone deacetylase 1, KDAC1
External IDs	OMIM: 601241; MGI: 108086; HomoloGene: 68426; GeneCards: HDAC1; OMA:HDAC1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	32,333,635 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	129,436,506 bp
RNA expression pattern
	Top expressed in
	mucosa of colon; ; mucosa of sigmoid colon; ; mucosa of transverse colon; ; epithelium of nasopharynx; ; rectum; ; lymph node; ; pylorus; ; right uterine tube; ; cecum; ; gums;
	Top expressed in
	tail of embryo; ; genital tubercle; ; morula; ; ventricular zone; ; bone marrow; ; yolk sac; ; thymus; ; embryo; ; blastocyst; ; placenta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; NAD-dependent histone deacetylase activity (H3-K14 specific); transcription corepressor activity; histone deacetylase activity; protein N-terminus binding; DNA-binding transcription factor activity; protein deacetylase activity; histone deacetylase binding; transcription cis-regulatory region binding; NF-kappaB binding; deacetylase activity; protein binding; nucleosomal DNA binding; enzyme binding; hydrolase activity; core promoter sequence-specific DNA binding; p53 binding; transcription factor binding; RNA polymerase II core promoter sequence-specific DNA binding; DNA binding; chromatin binding; Krueppel-associated box domain binding; E-box binding; promoter-specific chromatin binding;
Cellular component	cytoplasm; NuRD complex; cytosol; histone deacetylase complex; Sin3 complex; nucleoplasm; nucleus; chromatin; heterochromatin; transcription regulator complex; transcription repressor complex; protein-containing complex; soma; Sin3-type complex;
Biological process	hair follicle placode formation; epidermal cell differentiation; chromatin remodeling; regulation of transcription, DNA-templated; rhythmic process; negative regulation of androgen receptor signaling pathway; embryonic digit morphogenesis; negative regulation of apoptotic process; blood coagulation; negative regulation of transcription by RNA polymerase II; eyelid development in camera-type eye; circadian regulation of gene expression; negative regulation of gene expression; positive regulation of transcription, DNA-templated; odontogenesis of dentin-containing tooth; protein deacetylation; histone H4 deacetylation; fungiform papilla formation; negative regulation of myotube differentiation; viral process; histone deacetylation; negative regulation of canonical Wnt signaling pathway; positive regulation of transcription by RNA polymerase II; transcription, DNA-templated; regulation of signal transduction by p53 class mediator; DNA methylation-dependent heterochromatin assembly; beta-catenin-TCF complex assembly; chromatin organization; positive regulation of cell population proliferation; negative regulation of transcription, DNA-templated; histone H3 deacetylation; regulation of megakaryocyte differentiation; regulation of transcription by RNA polymerase II; endoderm development; circadian rhythm; hippocampus development; neuron differentiation; negative regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of oligodendrocyte differentiation; regulation of endopeptidase activity; regulation of amyloid-beta clearance; negative regulation of intrinsic apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3065
	433759
	ENSG00000116478
	ENSMUSG00000028800
	Q13547
	O09106
	NM_004964
	NM_008228
	NP_004955
	NP_032254
	Wikidata
View/Edit Human	View/Edit Mouse

Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116478 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028800 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Taunton J, Hassig CA, Schreiber SL (April 1996). "A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p". Science. 272 (5260): 408–11. Bibcode:1996Sci...272..408T. doi:10.1126/science.272.5260.408. PMID 8602529. S2CID 25717734.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116478 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028800 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8602529-5] Taunton J, Hassig CA, Schreiber SL (April 1996). "A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p". Science. 272 (5260): 408–11. Bibcode:1996Sci...272..408T. doi:10.1126/science.272.5260.408. PMID 8602529. S2CID 25717734.

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