HDAC11

HDAC11
Identifiers
Aliases	HDAC11, HD11, histone deacetylase 11
External IDs	OMIM: 607226; MGI: 2385252; HomoloGene: 11743; GeneCards: HDAC11; OMA:HDAC11 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	13,506,424 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	91,151,674 bp
RNA expression pattern
	Top expressed in
	left testis; ; inferior ganglion of vagus nerve; ; right testis; ; putamen; ; amygdala; ; caudate nucleus; ; C1 segment; ; nucleus accumbens; ; prefrontal cortex; ; globus pallidus;
	Top expressed in
	dorsomedial hypothalamic nucleus; ; superior colliculus; ; dorsal tegmental nucleus; ; ventral tegmental area; ; lateral hypothalamus; ; paraventricular nucleus of hypothalamus; ; anterior amygdaloid area; ; ventromedial nucleus; ; central gray substance of midbrain; ; Region I of hippocampus proper;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	NAD-dependent histone deacetylase activity (H3-K14 specific); transcription factor binding; hydrolase activity; histone deacetylase activity; protein binding;
Cellular component	histone deacetylase complex; plasma membrane; nucleus;
Biological process	histone H3 deacetylation; oligodendrocyte development; regulation of transcription, DNA-templated; histone deacetylation; transcription, DNA-templated; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	79885
	232232
	ENSG00000163517
	ENSMUSG00000034245
	Q96DB2
	Q91WA3
	NM_001136041; NM_024827; NM_001330636
	NM_144919
	NP_001129513; NP_001317565; NP_079103
	NP_659168
	Wikidata
View/Edit Human	View/Edit Mouse

Histone deacetylase 11 is a 39kDa histone deacetylase enzyme that in humans is encoded by the HDAC11 gene on chromosome 3 in humans and chromosome 6 in mice.^[5]^[6]

It is the only Class IV HDAC since it is not highly homologous with either Rpd3 or hda1 yeast enzymes and so does not fit into either Class I or Class II.^[7] It is the smallest HDAC isoform and it was first described in 2002.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163517 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034245 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gao L, Cueto MA, Asselbergs F, Atadja P (Jul 2002). "Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family". The Journal of Biological Chemistry. 277 (28): 25748–55. doi:10.1074/jbc.M111871200. PMID 11948178. S2CID 20332854.
^ "Entrez Gene: HDAC11 histone deacetylase 11".
^ Yang XJ, Seto E (Mar 2008). "The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men". Nature Reviews Molecular Cell Biology. 9 (3): 206–18. doi:10.1038/nrm2346. PMC 2667380. PMID 18292778.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163517 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034245 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11948178-5] Gao L, Cueto MA, Asselbergs F, Atadja P (Jul 2002). "Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family". The Journal of Biological Chemistry. 277 (28): 25748–55. doi:10.1074/jbc.M111871200. PMID 11948178. S2CID 20332854.

[entrez-6] "Entrez Gene: HDAC11 histone deacetylase 11".

[7] Yang XJ, Seto E (Mar 2008). "The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men". Nature Reviews Molecular Cell Biology. 9 (3): 206–18. doi:10.1038/nrm2346. PMC 2667380. PMID 18292778.

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