HDAC9

HDAC9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TQE
Identifiers
Aliases	HDAC9, HD7, HD7b, HD9, HDAC, HDAC7, HDAC7B, HDAC9B, HDAC9FL, HDRP, MITR, histone deacetylase 9
External IDs	OMIM: 606543; MGI: 1931221; HomoloGene: 128578; GeneCards: HDAC9; OMA:HDAC9 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	19,002,416 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	34,967,094 bp
RNA expression pattern
	Top expressed in
	oocyte; ; monocyte; ; secondary oocyte; ; endothelial cell; ; Epithelium of choroid plexus; ; parotid gland; ; ganglionic eminence; ; Skeletal muscle tissue of rectus abdominis; ; ventricular zone; ; gonad;
	Top expressed in
	interventricular septum; ; neural layer of retina; ; secondary oocyte; ; zygote; ; dentate gyrus of hippocampal formation granule cell; ; Region I of hippocampus proper; ; ascending aorta; ; visual cortex; ; piriform cortex; ; left ventricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	NAD-dependent histone deacetylase activity (H3-K14 specific); transcription corepressor activity; histone deacetylase activity; protein deacetylase activity; transcription factor binding; histone deacetylase binding; metal ion binding; protein binding; hydrolase activity; protein kinase C binding; histone deacetylase activity (H4-K16 specific);
Cellular component	cytoplasm; histone deacetylase complex; transcription regulator complex; nucleoplasm; nucleus; histone methyltransferase complex;
Biological process	histone H3 deacetylation; peptidyl-lysine deacetylation; regulation of transcription, DNA-templated; positive regulation of cell migration involved in sprouting angiogenesis; response to amphetamine; negative regulation of transcription by RNA polymerase II; regulation of striated muscle cell differentiation; transcription, DNA-templated; B cell activation; heart development; histone H4 deacetylation; neuron differentiation; cellular response to insulin stimulus; regulation of skeletal muscle fiber development; B cell differentiation; inflammatory response; negative regulation of transcription, DNA-templated; chromatin organization; histone deacetylation; cholesterol homeostasis; negative regulation of lipoprotein lipase activity; histone H4-K16 deacetylation;
	Sources:Amigo / QuickGO
Orthologs
	9734
	79221
	ENSG00000048052
	ENSMUSG00000004698
	Q9UKV0
	Q99N13
NM_001204144; NM_001204145; NM_001204146; NM_001204147; NM_001204148;
	NM_014707; NM_058176; NM_058177; NM_178423; NM_178425; NM_001321868; NM_001321869; NM_001321870; NM_001321871; NM_001321872; NM_001321873; NM_001321874; NM_001321875; NM_001321876; NM_001321877; NM_001321878; NM_001321879; NM_001321884; NM_001321885; NM_001321886; NM_001321887; NM_001321888; NM_001321889; NM_001321890; NM_001321891; NM_001321893; NM_001321894; NM_001321895; NM_001321896; NM_001321897; NM_001321898; NM_001321899; NM_001321900; NM_001321901; NM_001321902
	NM_001271386; NM_024124
NP_001191073; NP_001191074; NP_001191075; NP_001191076; NP_001191077;
	NP_001308797; NP_001308798; NP_001308799; NP_001308800; NP_001308801; NP_001308802; NP_001308803; NP_001308804; NP_001308805; NP_001308806; NP_001308807; NP_001308808; NP_001308813; NP_001308814; NP_001308815; NP_001308816; NP_001308817; NP_001308818; NP_001308819; NP_001308820; NP_001308822; NP_001308823; NP_001308824; NP_001308825; NP_001308826; NP_001308827; NP_001308828; NP_001308829; NP_001308830; NP_001308831; NP_055522; NP_478056; NP_848510; NP_848512
	NP_001258315; NP_077038
	Wikidata
View/Edit Human	View/Edit Mouse

Histone deacetylase 9 is an enzyme that in humans is encoded by the HDAC9 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000048052 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004698 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang AH, Bertos NR, Vezmar M, Pelletier N, Crosato M, Heng HH, et al. (November 1999). "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor". Molecular and Cellular Biology. 19 (11): 7816–7827. doi:10.1128/mcb.19.11.7816. PMC 84849. PMID 10523670.
^ Sparrow DB, Miska EA, Langley E, Reynaud-Deonauth S, Kotecha S, Towers N, et al. (September 1999). "MEF-2 function is modified by a novel co-repressor, MITR". The EMBO Journal. 18 (18): 5085–5098. doi:10.1093/emboj/18.18.5085. PMC 1171579. PMID 10487760.
^ "Entrez Gene: HDAC9 histone deacetylase 9".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000048052 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004698 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10523670-5] Wang AH, Bertos NR, Vezmar M, Pelletier N, Crosato M, Heng HH, et al. (November 1999). "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor". Molecular and Cellular Biology. 19 (11): 7816–7827. doi:10.1128/mcb.19.11.7816. PMC 84849. PMID 10523670.

[pmid10487760-6] Sparrow DB, Miska EA, Langley E, Reynaud-Deonauth S, Kotecha S, Towers N, et al. (September 1999). "MEF-2 function is modified by a novel co-repressor, MITR". The EMBO Journal. 18 (18): 5085–5098. doi:10.1093/emboj/18.18.5085. PMC 1171579. PMID 10487760.

[entrez-7] "Entrez Gene: HDAC9 histone deacetylase 9".

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