HER2

ERBB2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, erb-b2 receptor tyrosine kinase 2
External IDsOMIM: 164870; MGI: 95410; HomoloGene: 3273; GeneCards: ERBB2; OMA:ERBB2 - orthologs
EC number2.7.10.1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001005862
NM_001289936
NM_001289937
NM_001289938
NM_004448

NM_001003817
NM_010152

RefSeq (protein)

NP_001003817

Location (UCSC)Chr 17: 39.69 – 39.73 MbChr 11: 98.3 – 98.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Receptor tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. The human protein is also frequently referred to as HER2 (human epidermal growth factor receptor 2) or CD340 (cluster of differentiation 340).[5][6][7]

HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. But contrary to other members of the ERBB family, HER2 does not directly bind ligand. HER2 activation results from heterodimerization with another ERBB member or by homodimerization when HER2 concentration are high, for instance in cancer.[8] Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients.[9]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141736Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062312Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "ERBB2 erb-b2 receptor tyrosine kinase 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-06-14.
  6. ^ "ERBB2". Genetics Home Reference. Retrieved 2016-06-19.
  7. ^ Barh D, Gunduz M (2015-01-22). Noninvasive Molecular Markers in Gynecologic Cancers. CRC Press. p. 427. ISBN 978-1-4665-6939-3.
  8. ^ Hsu JL, Hung MC (2016). "The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer". Cancer and Metastasis Reviews. 35 (4): 575–588. doi:10.1007/s10555-016-9649-6. PMC 5215954. PMID 27913999.
  9. ^ Cite error: The named reference pmid23320171 was invoked but never defined (see the help page).