HES1

HES1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MH3
Identifiers
Aliases	HES1, HES-1, HHL, HRY, bHLHb39, hes family bHLH transcription factor 1
External IDs	OMIM: 139605; MGI: 104853; HomoloGene: 38067; GeneCards: HES1; OMA:HES1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q29 Start 194,136,148 bp[1] End 194,138,732 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 B2|16 21.09 cM Start 29,883,202 bp[2] End 29,886,614 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla ventricular zone nipple mucosa of pharynx urethra saphenous vein pylorus pericardium vena cava body of tongue Top expressed in lip transitional epithelium of urinary bladder ventricular zone middle ear ciliary body embryo tail of embryo Eustachian tube bile duct hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein dimerization activity DNA-binding transcription factor activity histone deacetylase binding transcription factor binding protein binding sequence-specific DNA binding chaperone binding DNA-binding transcription repressor activity, RNA polymerase II-specific N-box binding protein homodimerization activity DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription corepressor activity E-box binding sequence-specific double-stranded DNA binding Cellular component cytoplasm intracellular anatomical structure nucleus nucleoplasm Biological process pattern specification process auditory receptor cell fate determination midbrain-hindbrain boundary morphogenesis inner ear receptor cell stereocilium organization negative regulation of neuron differentiation metanephric nephron tubule morphogenesis cell morphogenesis involved in neuron differentiation regulation of transcription by RNA polymerase II lateral inhibition cardiac neural crest cell development involved in outflow tract morphogenesis negative regulation of stem cell differentiation inner ear auditory receptor cell differentiation negative regulation of pro-B cell differentiation negative regulation of inner ear receptor cell differentiation regulation of neurogenesis positive regulation of Notch signaling pathway cochlea development cell fate commitment regulation of transcription, DNA-templated lung development negative regulation of inner ear auditory receptor cell differentiation negative regulation of cell differentiation labyrinthine layer blood vessel development in utero embryonic development cell maturation adenohypophysis development regulation of timing of neuron differentiation regulation of fat cell differentiation transcription, DNA-templated positive regulation of transcription, DNA-templated telencephalon development positive regulation of T cell proliferation neural tube development pancreas development hindbrain morphogenesis smoothened signaling pathway negative regulation of stomach neuroendocrine cell differentiation ureteric bud morphogenesis regulation of inner ear auditory receptor cell differentiation oculomotor nerve development regulation of timing of cell differentiation nervous system development cell adhesion positive regulation of BMP signaling pathway midbrain development establishment of epithelial cell polarity pituitary gland development comma-shaped body morphogenesis somatic stem cell population maintenance trochlear nerve development aorta morphogenesis negative regulation of forebrain neuron differentiation negative regulation of pancreatic A cell differentiation regulation of secondary heart field cardioblast proliferation common bile duct development renal interstitial fibroblast development forebrain radial glial cell differentiation S-shaped body morphogenesis glomerulus vasculature development liver development regulation of epithelial cell proliferation cell migration positive regulation of transcription by RNA polymerase II ventricular septum morphogenesis negative regulation of oligodendrocyte differentiation ascending aorta morphogenesis outflow tract morphogenesis positive regulation of astrocyte differentiation ventricular septum development vascular associated smooth muscle cell development embryonic heart tube morphogenesis positive regulation of receptor signaling pathway via JAK-STAT Notch signaling pathway positive regulation of mitotic cell cycle, embryonic negative regulation of transcription, DNA-templated thymus development positive regulation of DNA binding negative regulation of glial cell proliferation neuronal stem cell population maintenance positive regulation of cell population proliferation negative regulation of transcription by RNA polymerase II artery morphogenesis pharyngeal arch artery morphogenesis positive regulation of tyrosine phosphorylation of STAT protein protein-containing complex assembly regulation of receptor signaling pathway via JAK-STAT somitogenesis cell differentiation anterior/posterior pattern specification negative regulation of cell fate determination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3280 15205 Ensembl ENSG00000114315 ENSMUSG00000022528 UniProt Q14469 P35428 RefSeq (mRNA) NM_005524 NM_008235 RefSeq (protein) NP_005515 NP_032261 Location (UCSC) Chr 3: 194.14 – 194.14 Mb Chr 16: 29.88 – 29.89 Mb PubMed search [3] [4]
Wikidata
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Transcription factor HES1 (hairy and enhancer of split-1) is a protein that is encoded by the Hes1 gene, and is the mammalian homolog of the hairy gene in Drosophila.^[5][6] HES1 is one of the seven members of the Hes gene family (HES1-7). Hes genes code nuclear proteins that suppress transcription.^[7]

This protein belongs to the basic helix-loop-helix (bHLH) family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box promoter region rather than the canonical enhancer box (E-box).^[6] As a member of the bHLH family, it is a transcriptional repressor that influences cell proliferation and differentiation in embryogenesis.^[7] HES1 regulates its own expression via a negative feedback loop, and oscillates with approximately 2-hour periodicity.^[8]