HES3

HES3
Identifiers
Aliases	HES3, bHLHb43, hes family bHLH transcription factor 3
External IDs	OMIM: 609971; MGI: 104877; HomoloGene: 7358; GeneCards: HES3; OMA:HES3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	6,245,578 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	152,376,119 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa;
	Top expressed in
	urethra; ; male urethra; ; female urethra; ; cerebellar cortex; ; embryo; ; hair; ; tail of embryo; ; Purkinje cell; ; adrenal medulla; ; pars intermedia;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; transcription factor binding; protein dimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription corepressor activity; sequence-specific DNA binding; sequence-specific double-stranded DNA binding;
Cellular component	nucleus;
Biological process	hindbrain morphogenesis; trochlear nerve development; midbrain-hindbrain boundary morphogenesis; negative regulation of transcription, DNA-templated; in utero embryonic development; negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; regulation of timing of neuron differentiation; regulation of neurogenesis; oculomotor nerve development; transcription, DNA-templated; midbrain development; positive regulation of transcription by RNA polymerase II; neural tube development; somitogenesis; Notch signaling pathway; cell differentiation; anterior/posterior pattern specification;
	Sources:Amigo / QuickGO
Orthologs
	390992
	15207
	ENSG00000173673
	ENSMUSG00000028946
	Q5TGS1
	Q61657
	NM_001024598
	NM_008237
	NP_001019769
	NP_032263; NP_001390720; NP_001390721; NP_001390722; NP_001390723
	Wikidata
View/Edit Human	View/Edit Mouse

Hes family bHLH transcription factor 3 is a protein that in humans is encoded by the HES3 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173673 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028946 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Hes family bHLH transcription factor 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173673 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028946 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Hes family bHLH transcription factor 3".

[1]

[2]

[3]

[4]

[5]