HEY1

HEY1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DB7
Identifiers
Aliases	HEY1, BHLHb31, CHF2, HERP2, HESR1, HRT-1, OAF1, hHRT1, hes related family bHLH transcription factor with YRPW motif 1, NERP2
External IDs	OMIM: 602953; MGI: 1341800; HomoloGene: 7756; GeneCards: HEY1; OMA:HEY1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	79,767,857 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	8,732,316 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; optic nerve; ; middle temporal gyrus; ; dorsal motor nucleus of vagus nerve; ; spinal ganglia; ; trigeminal ganglion; ; internal globus pallidus; ; visceral pleura; ; mucosa of paranasal sinus;
	Top expressed in
	pharyngeal groove; ; molar; ; ventricular zone; ; aortic valve; ; right lung lobe; ; nasal epithelium; ; olfactory epithelium; ; renal corpuscle; ; tail of embryo; ; left lung;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	microsatellite binding; DNA binding; protein dimerization activity; DNA-binding transcription factor activity; transcription factor binding; RNA polymerase II general transcription initiation factor activity; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; transcription corepressor activity; sequence-specific DNA binding; sequence-specific double-stranded DNA binding;
Cellular component	cytoplasm; nucleoplasm; nucleus;
Biological process	dorsal aorta morphogenesis; pulmonary valve morphogenesis; negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; regulation of transcription, DNA-templated; heart trabecula formation; regulation of vasculogenesis; cardiac septum morphogenesis; ventricular septum morphogenesis; labyrinthine layer blood vessel development; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; endocardial cushion morphogenesis; multicellular organism development; atrioventricular valve formation; arterial endothelial cell differentiation; cellular response to glucocorticoid stimulus; umbilical cord morphogenesis; negative regulation of transcription regulatory region DNA binding; angiogenesis; negative regulation of transcription, DNA-templated; cardiac ventricle morphogenesis; positive regulation of transcription by RNA polymerase II; negative regulation of Notch signaling pathway; cardiac epithelial to mesenchymal transition; Notch signaling involved in heart development; Notch signaling pathway; positive regulation of transcription, DNA-templated; blood vessel development; heart development; cell differentiation; regulation of neurogenesis; positive regulation of gene expression; negative regulation of biomineral tissue development; anterior/posterior pattern specification; negative regulation of neuron differentiation; circulatory system development;
	Sources:Amigo / QuickGO
Orthologs
	23462
	15213
	ENSG00000164683
	ENSMUSG00000040289
	Q9Y5J3
	Q9WV93; Q9QUM5
	NM_012258; NM_001040708; NM_001282851
	NM_010423
	NP_001035798; NP_001269780; NP_036390
	NP_034553
	Wikidata
View/Edit Human	View/Edit Mouse

Hairy/enhancer-of-split related with YRPW motif protein 1 is a protein that in humans is encoded by the HEY1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164683 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040289 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Leimeister C, Externbrink A, Klamt B, Gessler M (Jul 1999). "Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis". Mechanisms of Development. 85 (1–2): 173–7. doi:10.1016/S0925-4773(99)00080-5. PMID 10415358. S2CID 17342136.
^ Kokubo H, Lun Y, Johnson RL (Jul 1999). "Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split". Biochemical and Biophysical Research Communications. 260 (2): 459–65. doi:10.1006/bbrc.1999.0880. PMID 10403790.
^ "Entrez Gene: HEY1 hairy/enhancer-of-split related with YRPW motif 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164683 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040289 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10415358-5] Leimeister C, Externbrink A, Klamt B, Gessler M (Jul 1999). "Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis". Mechanisms of Development. 85 (1–2): 173–7. doi:10.1016/S0925-4773(99)00080-5. PMID 10415358. S2CID 17342136.

[pmid10403790-6] Kokubo H, Lun Y, Johnson RL (Jul 1999). "Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split". Biochemical and Biophysical Research Communications. 260 (2): 459–65. doi:10.1006/bbrc.1999.0880. PMID 10403790.

[entrez-7] "Entrez Gene: HEY1 hairy/enhancer-of-split related with YRPW motif 1".

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