HIC2

HIC2
Identifiers
Aliases	HIC2, HRG22, ZBTB30, ZNF907, hypermethylated in cancer 2, HIC ZBTB transcriptional repressor 2
External IDs	OMIM: 607712; MGI: 1929869; HomoloGene: 9020; GeneCards: HIC2; OMA:HIC2 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	21,451,463 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	17,081,294 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; amniotic fluid; ; endothelial cell; ; placenta; ; gonad; ; vena cava; ; Brodmann area 23; ; parotid gland; ; Region I of hippocampus proper; ; gingival epithelium;
	Top expressed in
	zygote; ; secondary oocyte; ; yolk sac; ; female urethra; ; blastocyst; ; abdominal wall; ; mandibular prominence; ; maxillary prominence; ; primitive streak; ; epiblast;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein C-terminus binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	23119
	58180
	ENSG00000169635
	ENSMUSG00000050240
	Q96JB3
	Q9JLZ6
	NM_015094
	NM_178922
	NP_055909
	NP_849253
	Wikidata
View/Edit Human	View/Edit Mouse

Hypermethylated in cancer 2 protein is a protein that in humans is encoded by the HIC2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169635 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050240 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Deltour S, Pinte S, Guerardel C, Leprince D (Sep 2001). "Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1". Biochem Biophys Res Commun. 287 (2): 427–34. doi:10.1006/bbrc.2001.5624. PMID 11554746.
^ "Entrez Gene: HIC2 hypermethylated in cancer 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169635 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050240 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11554746-5] Deltour S, Pinte S, Guerardel C, Leprince D (Sep 2001). "Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1". Biochem Biophys Res Commun. 287 (2): 427–34. doi:10.1006/bbrc.2001.5624. PMID 11554746.

[entrez-6] "Entrez Gene: HIC2 hypermethylated in cancer 2".

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