HIF3A

HIF3A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4WN5
Identifiers
Aliases	HIF3A, HIF-3A, IPAS, MOP7, PASD7, bHLHe17, HIF3-alpha-1, hypoxia inducible factor 3 alpha subunit, hypoxia inducible factor 3 subunit alpha
External IDs	OMIM: 609976; MGI: 1859778; HomoloGene: 9646; GeneCards: HIF3A; OMA:HIF3A - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	46,343,433 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	16,796,352 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; apex of heart; ; right lung; ; left uterine tube; ; muscle layer of sigmoid colon; ; right auricle; ; sural nerve; ; left ventricle; ; popliteal artery; ; tibial arteries;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; left lung lobe; ; external carotid artery; ; internal carotid artery; ; fossa; ; human fetus; ; atrium; ; efferent ductule; ; umbilical cord; ; migratory enteric neural crest cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein dimerization activity; transcription corepressor activity; DNA-binding transcription factor activity; transcription coactivator activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nuclear speck; mitochondrion; nucleoplasm; cytosol; plasma membrane; nucleus;
Biological process	response to hypoxia; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription, DNA-templated; multicellular organism development; angiogenesis; regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription by RNA polymerase II; apoptotic process; negative regulation of nucleic acid-templated transcription; cellular response to hypoxia; post-translational protein modification; positive regulation of nucleic acid-templated transcription; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	64344
	53417
	ENSG00000124440
	ENSMUSG00000004328
	Q9Y2N7
	Q0VBL6
	NM_022462; NM_152794; NM_152795; NM_152796
	NM_001162950; NM_016868
	NP_071907; NP_690007; NP_690008; NP_690009
	NP_001156422; NP_058564
	Wikidata
View/Edit Human	View/Edit Mouse

Hypoxia-inducible factor 3 alpha is a protein that in humans is encoded by the HIF3A gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124440 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004328 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hara S, Hamada J, Kobayashi C, Kondo Y, Imura N (Sep 2001). "Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha". Biochem Biophys Res Commun. 287 (4): 808–13. doi:10.1006/bbrc.2001.5659. PMID 11573933.
^ Makino Y, Cao R, Svensson K, Bertilsson G, Asman M, Tanaka H, Cao Y, Berkenstam A, Poellinger L (Dec 2001). "Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression". Nature. 414 (6863): 550–4. Bibcode:2001Natur.414..550M. doi:10.1038/35107085. PMID 11734856. S2CID 4389117.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124440 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004328 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11573933-5] Hara S, Hamada J, Kobayashi C, Kondo Y, Imura N (Sep 2001). "Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha". Biochem Biophys Res Commun. 287 (4): 808–13. doi:10.1006/bbrc.2001.5659. PMID 11573933.

[pmid11734856-6] Makino Y, Cao R, Svensson K, Bertilsson G, Asman M, Tanaka H, Cao Y, Berkenstam A, Poellinger L (Dec 2001). "Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression". Nature. 414 (6863): 550–4. Bibcode:2001Natur.414..550M. doi:10.1038/35107085. PMID 11734856. S2CID 4389117.

[entrez-7] Cite error: The named reference entrez was invoked but never defined (see the help page).

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