HIST1H4L

H4C13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4H9O, 3WKJ, 3AYW, 3WA9, 5B0Z, 5AVB, 2CV5, 5AV5, 3AV2, 3WTP, 3AV1, 3AZK, 3X1V, 5AV8, 1F66, 4QUU, 3CFS, 4YYK, 4QUT, 3NQJ, 3A6N, 3W99, 5AVC, 2RS9, 3F9Z, 3QZT, 3QBY, 3W97, 4M38, 4YM6, 3CFV, 4HGA, 1EQZ, 2RJE, 3QZV, 1HQ3, 4H9P, 3AZL, 3AFA, 1TZY, 3UVY, 5CPK, 3JPX, 4U9W, 4N3W, 4YYJ, 4YYD, 4H9N, 4H9R, 3AZI, 4LD9, 3UVX, 3AZH, 5BNX, 4N4F, 1U35, 4YYG, 3O36, 2ARO, 5AV9, 4H9S, 3AZF, 3W98, 4GQB, 4H9Q, 5BNV, 3WAA, 3AZG, 3AZE, 2RNY, 1ZKK, 2QQS, 2LVM, 3X1T, 3AN2, 2KWO, 3QZS, 3F9W, 5FFW, 5CPJ, 3F9X, 3IJ1, 4YM5, 3AZJ, 4YY6, 3AZN, 2IG0, 4YYH, 4YYI, 5CPI, 3W96, 3R45, 2KWN, 3F9Y, 5AV6, 3AZM, 5BO0, 3X1S, 4QYD, 4KGC, 3UVW, 4YYN, 3X1U, 3UW9, 2F8N, 3NQU, 5B0Y, 4YYM, 5C3I, 4Z5T, 5B24, 5FA5, 4Z2M, 5E5A, 5FWE, 5B2I, 5B40, 5B2J, 5JA4, 5AY8, 4ZUX
Identifiers
Aliases	H4C13, H4.k, H4/k, H4FK, histone cluster 1, H4l, histone cluster 1 H4 family member l, HIST1H4L, H4 clustered histone 13, H4C5, H4C4, H4C9, H4C12, H4-16, H4C3, H4C11, H4C1, H4C14, H4C15, H4C8, H4C6, H4C2
External IDs	OMIM: 602831; MGI: 4843992; HomoloGene: 136248; GeneCards: H4C13; OMA:H4C13 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	27,873,534 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	22,016,366 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; epithelium of colon; ; Achilles tendon; ; mucosa of transverse colon; ; granulocyte; ; tonsil; ; corpus callosum; ; ventricular zone; ; ganglionic eminence; ; blood;
	Top expressed in
	spermatid; ; spermatocyte; ; embryo; ; uterus; ; granulocyte; ; bone marrow; ; embryo; ; blastocyst; ; mesencephalon; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein domain specific binding; protein binding; protein heterodimerization activity; DNA binding; histone binding; RNA binding;
Cellular component	membrane; chromosome; nucleoplasm; extracellular region; nuclear chromosome; nucleosome; extracellular exosome; nucleus; extracellular matrix; protein-containing complex;
Biological process	telomere organization; epigenetic maintenance of chromatin in transcription-competent conformation; protein heterotetramerization; negative regulation of megakaryocyte differentiation; CENP-A containing chromatin assembly; DNA replication-dependent chromatin assembly; rDNA heterochromatin assembly; negative regulation of gene expression, epigenetic; DNA-templated transcription, initiation; double-strand break repair via nonhomologous end joining; beta-catenin-TCF complex assembly; telomere capping; nucleosome assembly; regulation of gene silencing by miRNA; regulation of megakaryocyte differentiation; regulation of hematopoietic stem cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	8368
	319161
	ENSG00000275126
	ENSMUSG00000069305
	P62805
	P62806
	NM_003546
	NM_175657
NP_003537; NP_003486; NP_003535; NP_003539; NP_003531;
	NP_003536
NP_291074; NP_783587; NP_783588; NP_835499; NP_835500;
	NP_001182350; NP_835515; NP_783585; NP_783586; NP_835582; NP_835583; NP_783583; NP_694813
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H4 is a protein that in humans is encoded by the HIST1H4L gene.^[5]^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000275126 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000069305 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Albig W, Meergans T, Doenecke D (Mar 1997). "Characterization of the H1.5 gene completes the set of human H1 subtype genes". Gene. 184 (2): 141–8. doi:10.1016/S0378-1119(96)00582-3. PMID 9031620.
^ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.
^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
^ "Entrez Gene: HIST1H4L histone cluster 1, H4l".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000275126 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000069305 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9031620-5] Albig W, Meergans T, Doenecke D (Mar 1997). "Characterization of the H1.5 gene completes the set of human H1 subtype genes". Gene. 184 (2): 141–8. doi:10.1016/S0378-1119(96)00582-3. PMID 9031620.

[pmid9439656-6] Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.

[pmid12408966-7] Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.

[entrez-8] "Entrez Gene: HIST1H4L histone cluster 1, H4l".

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