HLA-A66

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HLA-A66
(MHC Class I, A cell surface antigen)
HLA-A66
About
Protein	transmembrane receptor/ligand
Structure	αβ heterodimer
Subunits	HLA-A*66--, β2-microglobulin
Older names	A10
Subtypes
Subtype allele Available structures A66.1 *6601 A66.2 *6602 {{{cNick3}}} *66{{{cAllele3}}} {{{cNick4}}} *66{{{cAllele4}}}
Rare alleles
Subtype allele Available structures A66.3 *6603 {{{rnick2}}} *66{{{rallele2}}} {{{rnick3}}} *66{{{rallele3}}}
Alleles link-out to IMGT/HLA database at EBI

HLA-A66 (A66) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α⁶⁶ subset of HLA-A α-chains. For A66, the alpha "A" chain are encoded by the HLA-A*66 allele group and the β-chain are encoded by B2M locus.^[1] A66 and A*66 are almost synonymous in meaning. A66 is a split antigen of the broad antigen serotype A10. A66 is a sister serotype of A25, A26, A34, and A43.

A66 is more common in Africa and Southwest Europe. A66 (A*6601) is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.^[2].

A66 serotyping is poor. A*6601 is also sometimes recognized by A25, and A*6602 is often recognized by A74.