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major histocompatibility complex, class II, DR3
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| Haplotypes groups | DRA*01:DRB1*03:01 DRA*01:DRB1*03:02 DRA*01:DRB1*03:03 DRA*01:DRB1*03:04 | |
| Structure (See HLA-DR) | ||
| Identifiers | alpha *01:01
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| Symbol(s) | HLA-DRA[permanent dead link] | |
| EBI-HLA | DRA*01:01 | |
| Identifiers | beta 1 *03:01 *03:01 *03:02 *03:03 *03:04
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| Symbol(s) | HLA-DRB1[permanent dead link] | |
| EBI-HLA | DRB1*03:01 | |
| EBI-HLA | DRB1*03:02 | |
| EBI-HLA | DRB1*03:03 | |
| EBI-HLA | DRB1*03:04 | |
| EBI-HLA | DRB1*03:05 Archived 2007-09-26 at the Wayback Machine | |
| Shared data | ||
| Locus | chr.6 6p21.31 | |
HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease. Type 1 diabetes mellitus is associated with HLA-DR3 or HLA-DR4. Nearly half the US population has either DR3 or DR4 (only 1–3% have both), yet only a small percentage (about 0.5%) of these individuals will develop type 1 diabetes.