HLA-DR3

Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
major histocompatibility complex, class II, DR3
Haplotypes groups DRA*01:DRB1*03:01 DRA*01:DRB1*03:02 DRA*01:DRB1*03:03 DRA*01:DRB1*03:04
Structure (See HLA-DR)
Identifiers
alpha *01:01
Symbol(s) HLA-DRA[permanent dead link]
EBI-HLA DRA*01:01
Identifiers
beta 1 *03:01 *03:01 *03:02 *03:03 *03:04
Symbol(s) HLA-DRB1[permanent dead link]
EBI-HLA DRB1*03:01
EBI-HLA DRB1*03:02
EBI-HLA DRB1*03:03
EBI-HLA DRB1*03:04
EBI-HLA DRB1*03:05 Archived 2007-09-26 at the Wayback Machine
Shared data
Locus chr.6 6p21.31

HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease. Type 1 diabetes mellitus is associated with HLA-DR3 or HLA-DR4. Nearly half the US population has either DR3 or DR4 (only 1–3% have both), yet only a small percentage (about 0.5%) of these individuals will develop type 1 diabetes.