HMGB4

HMGB4
Identifiers
Aliases	HMGB4, dJ1007G16.5, high mobility group box 4
External IDs	OMIM: 617285; MGI: 1916567; HomoloGene: 83321; GeneCards: HMGB4; OMA:HMGB4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	33,864,791 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	128,154,750 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; sperm; ; testicle; ; tail of epididymis; ; right coronary artery; ; caput epididymis; ; ectocervix; ; right uterine tube; ; canal of the cervix;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; muscle tissue; ; central gray substance of midbrain; ; striated muscle tissue; ; pancreas; ; skeletal muscle tissue; ; islet of Langerhans; ; hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; DNA binding; transcription factor binding; DNA binding, bending;
Cellular component	nucleus; chromosome; cytoplasm;
Biological process	activation of innate immune response; DNA recombination; chromatin remodeling; regulation of transcription by RNA polymerase II; regulation of signaling receptor activity; positive regulation of autophagy; developmental process; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of innate immune response; positive regulation of transcription by RNA polymerase II; cell chemotaxis; positive regulation of ERK1 and ERK2 cascade; positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologs
	127540
	69317
	ENSG00000176256
	ENSMUSG00000048686
	Q8WW32
	Q6P8W9
	NM_145205; NM_001352984; NM_001379301
	NM_027036
	NP_660206; NP_001339913; NP_001366230
	NP_081312
	Wikidata
View/Edit Human	View/Edit Mouse

High mobility group protein B4 is a transcription factor that in humans is encoded by the HMGB4 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000176256 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048686 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: high-mobility group box 4".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000176256 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048686 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: high-mobility group box 4".

[1]

[2]

[3]

[4]

[5]