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| Location | Usk, Monmouthshire, Wales |
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| Coordinates | 51°41′58″N 2°54′01″W / 51.69944°N 2.90028°W |
| Security class | Adult Male/Category C |
| Population | 280[1] (as of March 2020) |
| Opened | 1844 |
| Managed by | HM Prison Services |
| Governor | Rob Denman |
| Website | Usk at justice.gov.uk |
HM Prison Usk (Welsh: Carchar Brynbuga EF) is a Category C men's prison, located in Maryport Street in Usk, Monmouthshire, Wales. The prison is operated by His Majesty's Prison Service, and jointly managed with the nearby HMP Prescoed.