HOPX

HOPX
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UHS, 2HI3
Identifiers
Aliases	HOPX, CAMEO, HOD, HOP, LAGY, NECC1, OB1, SMAP31, TOTO, HOP homeobox
External IDs	OMIM: 607275; MGI: 1916782; HomoloGene: 15859; GeneCards: HOPX; OMA:HOPX - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	56,681,899 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	77,262,968 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; corpus epididymis; ; skin of hip; ; mucosa of pharynx; ; human penis; ; oral cavity; ; skin of abdomen; ; vulva; ; right lung; ; upper lobe of left lung;
	Top expressed in
	right lung lobe; ; left lung; ; superior surface of tongue; ; right ventricle; ; cardiac muscle tissue of left ventricle; ; left lung lobe; ; gastrula; ; esophagus; ; interventricular septum; ; transitional epithelium of urinary bladder;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus;
Biological process	regulation of transcription by RNA polymerase II; negative regulation of cell differentiation; multicellular organism development; regulation of transcription, DNA-templated; transcription, DNA-templated; trophectodermal cell differentiation; chaperone-mediated protein complex assembly; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	84525
	74318
	ENSG00000171476
	ENSMUSG00000059325
	Q9BPY8
	Q8R1H0
	NM_001145459; NM_001145460; NM_032495; NM_139211; NM_139212
	NM_001159900; NM_001159901; NM_175606
	NP_001138931; NP_001138932; NP_115884; NP_631957; NP_631958
	NP_001153372; NP_001153373; NP_783199
	Wikidata
View/Edit Human	View/Edit Mouse

Homeodomain-only protein is a protein that in humans is encoded by the HOPX gene.^[5] It is an important regulator of cardiac development^[6] and a marker of hippocampal neural stem cells.^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171476 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059325 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: HOP homeodomain-only protein".
^ Chen F, Kook H, Milewski R, Gitler AD, Lu MM, Li J, et al. (September 2002). "Hop is an unusual homeobox gene that modulates cardiac development". Cell. 110 (6): 713–723. doi:10.1016/S0092-8674(02)00932-7. PMID 12297045. S2CID 12189105.
^ Li D, Takeda N, Jain R, Manderfield LJ, Liu F, Li L, et al. (November 2015). "Hopx distinguishes hippocampal from lateral ventricle neural stem cells". Stem Cell Research. 15 (3): 522–529. doi:10.1016/j.scr.2015.09.015. PMC 4704104. PMID 26451648.
^ Berg DA, Su Y, Jimenez-Cyrus D, Patel A, Huang N, Morizet D, et al. (April 2019). "A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis". Cell. 177 (3): 654–668.e15. doi:10.1016/j.cell.2019.02.010. PMC 6496946. PMID 30929900.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171476 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059325 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: HOP homeodomain-only protein".

[Chen-6] Chen F, Kook H, Milewski R, Gitler AD, Lu MM, Li J, et al. (September 2002). "Hop is an unusual homeobox gene that modulates cardiac development". Cell. 110 (6): 713–723. doi:10.1016/S0092-8674(02)00932-7. PMID 12297045. S2CID 12189105.

[7] Li D, Takeda N, Jain R, Manderfield LJ, Liu F, Li L, et al. (November 2015). "Hopx distinguishes hippocampal from lateral ventricle neural stem cells". Stem Cell Research. 15 (3): 522–529. doi:10.1016/j.scr.2015.09.015. PMC 4704104. PMID 26451648.

[8] Berg DA, Su Y, Jimenez-Cyrus D, Patel A, Huang N, Morizet D, et al. (April 2019). "A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis". Cell. 177 (3): 654–668.e15. doi:10.1016/j.cell.2019.02.010. PMC 6496946. PMID 30929900.

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