HOXA11-AS1

HOXA11-AS lncRNA is a long non-coding RNA from the antisense strand in the homeobox A (HOXA gene). The HOX gene contains four clusters (A, B, C, and D). The sense strand of the HOXA gene codes for proteins. Alternative names for HOXA11-AS lncRNA are: HOXA-AS5, HOXA11S, HOXA11-AS1, HOXA11AS, or NCRNA00076. This gene is 3,885 nucleotides long and resides at chromosome 7 (7p15.2) and is transcribed from an independent gene promoter.[1][2] Being a lncRNA, it is longer than 200 nucleotides in length, in contrast to regular non-coding RNAs.[3]

The HOX genes code for transcription factors that are key to embryonic development.[4] This lncRNA is one of the three lncRNAs present in the 5-prime region of the HOXA11 gene. The other two lncRNAs are HOXA10-AS and HOTTIP. Of these lncRNAs, HOXA11-AS, is the most conserved sequence in a wide range of organisms, which shows its longevity in the phylogenetic tree.[5] Since HOX genes play a prominent role in embryogenesis and carcinogenesis, genes on the sense strand and antisense non-coding RNA (ncRNA) genes are often studied in their role of aberrant epithelial differentiation and cancer development.[5]

Location of HOXA11AS1 locus on chromosome 7
  1. ^ Zhang Y, Chen WJ, Gan TQ, Zhang XL, Xie ZC, Ye ZH, Deng Y, Wang ZF, Cai KT, Li SK, Luo DZ, Chen G (July 2017). "Clinical Significance and Effect of lncRNA HOXA11-AS in NSCLC: A Study Based on Bioinformatics, In Vitro and in Vivo Verification". Scientific Reports. 7 (1): 5567. Bibcode:2017NatSR...7.5567Z. doi:10.1038/s41598-017-05856-2. PMC 5514100. PMID 28717185.
  2. ^ Prensner JR, Chinnaiyan AM (October 2011). "The emergence of lncRNAs in cancer biology". Cancer Discovery. 1 (5): 391–407. doi:10.1158/2159-8290.CD-11-0209. PMC 3215093. PMID 22096659.
  3. ^ Spitale RC, Tsai MC, Chang HY (May 2011). "RNA templating the epigenome: long noncoding RNAs as molecular scaffolds". Epigenetics. 6 (5): 539–543. doi:10.4161/epi.6.5.15221. PMC 3230545. PMID 21393997.
  4. ^ Kung JT, Colognori D, Lee JT (March 2013). "Long noncoding RNAs: past, present, and future". Genetics. 193 (3): 651–669. doi:10.1534/genetics.112.146704. PMC 3583990. PMID 23463798.
  5. ^ a b Richards EJ, Permuth-Wey J, Li Y, Chen YA, Coppola D, Reid BM, Lin HY, Teer JK, Berchuck A, Birrer MJ, Lawrenson K, Monteiro AN, Schildkraut JM, Goode EL, Gayther SA, Sellers TA, Cheng JQ (October 2015). "A functional variant in HOXA11-AS, a novel long non-coding RNA, inhibits the oncogenic phenotype of epithelial ovarian cancer". Oncotarget. 6 (33): 34745–34757. doi:10.18632/oncotarget.5784. PMC 4741487. PMID 26430965.