HPGD

HPGD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GDZ
Identifiers
Aliases	HPGD, 15-PGDH, PGDH, PGDH1, PHOAR1, SDR36C1, hydroxyprostaglandin dehydrogenase 15-(NAD), 15-hydroxyprostaglandin dehydrogenase
External IDs	OMIM: 601688; MGI: 108085; HomoloGene: 68095; GeneCards: HPGD; OMA:HPGD - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	174,523,154 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	56,774,078 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; rectum; ; mucosa of colon; ; placenta; ; metanephric glomerulus; ; right lung; ; lower lobe of lung; ; mucosa of sigmoid colon; ; mucosa of transverse colon; ; mucosa of ileum;
	Top expressed in
	right lung lobe; ; seminal vesicula; ; wall of urinary bladder; ; mucosa of urinary bladder; ; transitional epithelium of urinary bladder; ; pyloric antrum; ; epithelium of stomach; ; left colon; ; body of femur; ; duodenum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	NAD binding; 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; catalytic activity; prostaglandin E receptor activity; NAD+ binding; oxidoreductase activity; protein homodimerization activity;
Cellular component	nucleoplasm; basolateral plasma membrane; extracellular exosome; cytoplasm; cytosol; extracellular space;
Biological process	prostaglandin metabolic process; thrombin-activated receptor signaling pathway; lipid metabolism; negative regulation of cell cycle; fatty acid metabolic process; lipoxygenase pathway; birth; lipoxin metabolic process; transforming growth factor beta receptor signaling pathway; ovulation; ductus arteriosus closure; response to lipopolysaccharide; kidney development; female pregnancy; response to estradiol; positive regulation of apoptotic process; response to ethanol; positive regulation of vascular associated smooth muscle cell proliferation; long-chain fatty acid biosynthetic process; lipoxin biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	3248
	15446
	ENSG00000164120
	ENSMUSG00000031613
	P15428
	Q8VCC1
NM_000860; NM_001145816; NM_001256301; NM_001256305; NM_001256306;
	NM_001256307; NM_001363574
	NM_008278
NP_000851; NP_001139288; NP_001243230; NP_001243234; NP_001243235;
	NP_001243236; NP_001350503
	NP_032304
	Wikidata
View/Edit Human	View/Edit Mouse

Hydroxyprostaglandin dehydrogenase 15-(NAD) (the HUGO-approved official symbol = HPGD; HGNC ID, HGNC:5154), also called 15-hydroxyprostaglandin dehydrogenase [NAD+], is an enzyme that in humans is encoded by the HPGD gene.^[5]^[6]

In melanocytic cells HPGD gene expression may be regulated by MITF.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164120 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031613 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
^ "Entrez Gene: HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)".
^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164120 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031613 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid19027726-5] Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.

[entrez-6] "Entrez Gene: HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)".

[pmid19067971-7] Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

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