HR (gene)

HR
Identifiers
Aliases	HR, ALUNC, AU, HSA277165, HYPT4, MUHH, MUHH1, hair growth associated, lysine demethylase and nuclear receptor corepressor, HR lysine demethylase and nuclear receptor corepressor
External IDs	OMIM: 602302; MGI: 96223; HomoloGene: 3774; GeneCards: HR; OMA:HR - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	22,133,384 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	70,810,988 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; skin of leg; ; right hemisphere of cerebellum; ; mucosa of transverse colon; ; vulva; ; right frontal lobe; ; nipple; ; sural nerve; ; prefrontal cortex; ; parotid gland;
	Top expressed in
	lip; ; hair bulb; ; muscle of thigh; ; Epithelium of large intestine; ; inner root sheath; ; esophagus; ; triceps brachii muscle; ; epithelium of rectum; ; skin of back; ; inner enamel epithelium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; oxidoreductase activity; transcription corepressor activity; metal ion binding; transcription cis-regulatory region binding; chromatin DNA binding; histone H3-methyl-lysine-9 demethylase activity;
Cellular component	nuclear body; nucleoplasm; chromatin; nucleus;
Biological process	negative regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription, DNA-templated; histone H3-K9 demethylation;
	Sources:Amigo / QuickGO
Orthologs
	55806
	15460
	ENSG00000168453
	ENSMUSG00000022096
	O43593
	Q61645
	NM_005144; NM_018411
	NM_021877; NM_001379479
	NP_005135; NP_060881
	NP_068677; NP_001366408
	Wikidata
View/Edit Human	View/Edit Mouse

HR is a gene encoding Protein hairless.^[5]^[6]^[7]

This gene encodes a protein whose function has been linked to hair growth. A similar protein in rat functions as a transcriptional corepressor for thyroid hormone and interacts with histone deacetylases.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168453 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022096 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ahmad W, Zlotogorski A, Panteleyev AA, Lam H, Ahmad M, ul Haque MF, Abdallah HM, Dragan L, Christiano AM (Apr 1999). "Genomic organization of the human hairless gene (HR) and identification of a mutation underlying congenital atrichia in an Arab Palestinian family". Genomics. 56 (2): 141–8. doi:10.1006/geno.1998.5699. PMID 10051399.
^ Nothen MM, Cichon S, Vogt IR, Hemmer S, Kruse R, Knapp M, Holler T, Faiyaz ul Haque M, Haque S, Propping P, Ahmad M, Rietschel M (Apr 1998). "A gene for universal congenital alopecia maps to chromosome 8p21-22". Am J Hum Genet. 62 (2): 386–90. doi:10.1086/301717. PMC 1376893. PMID 9463324.
^ ^a ^b "Entrez Gene: HR hairless homolog (mouse)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168453 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022096 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10051399-5] Ahmad W, Zlotogorski A, Panteleyev AA, Lam H, Ahmad M, ul Haque MF, Abdallah HM, Dragan L, Christiano AM (Apr 1999). "Genomic organization of the human hairless gene (HR) and identification of a mutation underlying congenital atrichia in an Arab Palestinian family". Genomics. 56 (2): 141–8. doi:10.1006/geno.1998.5699. PMID 10051399.

[pmid9463324-6] Nothen MM, Cichon S, Vogt IR, Hemmer S, Kruse R, Knapp M, Holler T, Faiyaz ul Haque M, Haque S, Propping P, Ahmad M, Rietschel M (Apr 1998). "A gene for universal congenital alopecia maps to chromosome 8p21-22". Am J Hum Genet. 62 (2): 386–90. doi:10.1086/301717. PMC 1376893. PMID 9463324.

[entrez-7] "Entrez Gene: HR hairless homolog (mouse)".

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