HSPBP1

HSPBP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XQR, 1XQS
Identifiers
Aliases	HSPBP1, FES1, HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1, HSPA (Hsp70) binding protein 1
External IDs	OMIM: 612939; MGI: 1913495; HomoloGene: 40827; GeneCards: HSPBP1; OMA:HSPBP1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	55,280,381 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	4,688,067 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; right uterine tube; ; caudate nucleus; ; putamen; ; right frontal lobe; ; apex of heart; ; cingulate gyrus; ; anterior cingulate cortex; ; amygdala; ; mucosa of transverse colon;
	Top expressed in
	spermatid; ; primary visual cortex; ; perirhinal cortex; ; right kidney; ; entorhinal cortex; ; superior frontal gyrus; ; morula; ; embryo; ; dentate gyrus of hippocampal formation granule cell; ; CA3 field;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	enzyme inhibitor activity; protein binding; adenyl-nucleotide exchange factor activity; ubiquitin protein ligase binding;
Cellular component	cytoplasm; endoplasmic reticulum;
Biological process	positive regulation of protein ubiquitination; protein folding; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of catalytic activity; regulation of catalytic activity;
	Sources:Amigo / QuickGO
Orthologs
	23640
	66245
	ENSG00000133265
	ENSMUSG00000063802
	Q9NZL4
	Q99P31
	NM_001130106; NM_001297600; NM_012267
	NM_024172; NM_001360629
	NP_001123578; NP_001284529; NP_036399
	NP_077134; NP_001347558
	Wikidata
View/Edit Human	View/Edit Mouse

Hsp70-binding protein 1 is a protein that in humans is encoded by the HSPBP1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000133265 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000063802 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Raynes DA, Guerriero V (Jan 2000). "Isolation and characterization of isoforms of HspBP1, inhibitors of Hsp70". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1490 (1–2): 203–7. doi:10.1016/s0167-4781(99)00238-9. PMID 10786638.
^ Raynes DA, Guerriero V (Dec 1998). "Inhibition of Hsp70 ATPase activity and protein renaturation by a novel Hsp70-binding protein". The Journal of Biological Chemistry. 273 (49): 32883–8. doi:10.1074/jbc.273.49.32883. PMID 9830037.
^ "Entrez Gene: HSPBP1 hsp70-interacting protein".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000133265 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000063802 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10786638-5] Raynes DA, Guerriero V (Jan 2000). "Isolation and characterization of isoforms of HspBP1, inhibitors of Hsp70". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1490 (1–2): 203–7. doi:10.1016/s0167-4781(99)00238-9. PMID 10786638.

[pmid9830037-6] Raynes DA, Guerriero V (Dec 1998). "Inhibition of Hsp70 ATPase activity and protein renaturation by a novel Hsp70-binding protein". The Journal of Biological Chemistry. 273 (49): 32883–8. doi:10.1074/jbc.273.49.32883. PMID 9830037.

[entrez-7] "Entrez Gene: HSPBP1 hsp70-interacting protein".

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