HTR3B

HTR3B
Identifiers
Aliases	HTR3B, 5-HT3B, 5-hydroxytryptamine receptor 3B
External IDs	OMIM: 604654; MGI: 1861899; HomoloGene: 38131; GeneCards: HTR3B; OMA:HTR3B - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	113,949,079 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	48,876,290 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; right frontal lobe; ; Brodmann area 9; ; anterior cingulate cortex; ; primary visual cortex; ; superior frontal gyrus; ; gonad; ; kidney; ; human kidney; ; amygdala;
	Top expressed in
	lumbar spinal ganglion; ; female external genitalia; ; urethra; ; autonomic nervous system; ; sympathetic ganglion; ; cervical ganglion; ; glossopharyngeal ganglion; ; stellate ganglion; ; embryo; ; tunica adventitia of aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	extracellular ligand-gated ion channel activity; ligand-gated ion channel activity; serotonin-gated cation-selective channel activity; ion channel activity; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; membrane; cell surface; plasma membrane; postsynaptic membrane; integral component of plasma membrane; serotonin-activated cation-selective channel complex; neuron projection; synapse;
Biological process	ion transport; signal transduction; ion transmembrane transport; serotonin receptor signaling pathway; chemical synaptic transmission; regulation of membrane potential; nervous system process;
	Sources:Amigo / QuickGO
Orthologs
	9177
	57014
	ENSG00000149305
	ENSMUSG00000008590
	O95264
	Q9JHJ5
	NM_006028; NM_001363563
	NM_020274
	NP_006019; NP_001350492
	NP_064670
	Wikidata
View/Edit Human	View/Edit Mouse

5-hydroxytryptamine (serotonin) receptor 3B, also known as HTR3B, is a human gene. The protein encoded by this gene is a subunit of the 5-HT3 receptor.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149305 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000008590 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, Kirkness EF (January 1999). "The 5-HT3B subunit is a major determinant of serotonin-receptor function". Nature. 397 (6717): 359–363. Bibcode:1999Natur.397..359D. doi:10.1038/16941. PMID 9950429. S2CID 4401851.
^ Dubin AE, Huvar R, D'Andrea MR, Pyati J, Zhu JY, Joy KC, Wilson SJ, Galindo JE, Glass CA, Luo L, Jackson MR, Lovenberg TW, Erlander MG (October 1999). "The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit". J. Biol. Chem. 274 (43): 30799–30810. doi:10.1074/jbc.274.43.30799. PMID 10521471.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000149305 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000008590 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9950429-5] Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, Kirkness EF (January 1999). "The 5-HT3B subunit is a major determinant of serotonin-receptor function". Nature. 397 (6717): 359–363. Bibcode:1999Natur.397..359D. doi:10.1038/16941. PMID 9950429. S2CID 4401851.

[pmid10521471-6] Dubin AE, Huvar R, D'Andrea MR, Pyati J, Zhu JY, Joy KC, Wilson SJ, Galindo JE, Glass CA, Luo L, Jackson MR, Lovenberg TW, Erlander MG (October 1999). "The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit". J. Biol. Chem. 274 (43): 30799–30810. doi:10.1074/jbc.274.43.30799. PMID 10521471.

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