HYAL1

HYAL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2PE4
Identifiers
Aliases	HYAL1, HYAL-1, LUCA1, NAT6, MPS9, hyaluronoglucosaminidase 1, hyaluronidase 1
External IDs	OMIM: 607071; MGI: 96298; HomoloGene: 5277; GeneCards: HYAL1; OMA:HYAL1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	50,312,381 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	107,458,909 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; spleen; ; apex of heart; ; left ventricle; ; human kidney; ; right lung; ; upper lobe of left lung; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland;
	Top expressed in
	hepatobiliary system; ; liver; ; proximal tubule; ; urinary bladder; ; white adipose tissue; ; genital tubercle; ; esophagus; ; lip; ; lung; ; zone of skin;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription factor binding; hydrolase activity, acting on glycosyl bonds; catalytic activity; hydrolase activity; hyaluronan synthase activity; hyalurononglucosaminidase activity;
Cellular component	cytoplasm; hyaluranon cable; extracellular region; lysosomal lumen; lysosome; extracellular exosome; cytoplasmic vesicle; extracellular space;
Biological process	hyaluronan biosynthetic process; hyaluronan catabolic process; positive regulation of hyaluranon cable assembly; positive regulation of epithelial cell proliferation; response to reactive oxygen species; response to antibiotic; cellular response to tumor necrosis factor; positive regulation of epithelial cell migration; cellular response to platelet-derived growth factor stimulus; positive regulation of growth; cellular response to fibroblast growth factor stimulus; positive regulation of angiogenesis; cellular response to pH; cartilage development; positive regulation of cell growth; cellular response to UV-B; negative regulation of cell growth; cellular response to interleukin-1; chondroitin sulfate catabolic process; embryonic skeletal joint morphogenesis; metabolism; inflammatory response; positive regulation of cell adhesion; hyaluronan metabolic process; positive regulation of G1/S transition of mitotic cell cycle; carbohydrate metabolic process; response to virus; viral entry into host cell;
	Sources:Amigo / QuickGO
Orthologs
	3373
	15586
	ENSG00000114378
	ENSMUSG00000010051
	Q12794
	Q91ZJ9
NM_033159; NM_153281; NM_153282; NM_153283; NM_153284;
	NM_153285; NM_153286
	NM_008317; NM_001331161
	NP_149349; NP_695013; NP_695014; NP_695015; NP_695017
	NP_001318090; NP_032343
	Wikidata
View/Edit Human	View/Edit Mouse

Hyaluronidase-1 is an enzyme that in humans is encoded by the HYAL1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114378 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000010051 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Frost GI, Csóka AB, Wong T, Stern R, Csóka TB (July 1997). "Purification, cloning, and expression of human plasma hyaluronidase". Biochemical and Biophysical Research Communications. 236 (1): 10–5. doi:10.1006/bbrc.1997.6773. PMID 9223416.
^ Csóka AB, Frost GI, Wong T, Stern R, Csóka TB (November 1997). "Purification and microsequencing of hyaluronidase isozymes from human urine". FEBS Letters. 417 (3): 307–10. Bibcode:1997FEBSL.417..307C. doi:10.1016/S0014-5793(97)01309-4. PMID 9409739. S2CID 44929703.
^ "Entrez Gene: HYAL1 hyaluronoglucosaminidase 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000114378 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000010051 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9223416-5] Frost GI, Csóka AB, Wong T, Stern R, Csóka TB (July 1997). "Purification, cloning, and expression of human plasma hyaluronidase". Biochemical and Biophysical Research Communications. 236 (1): 10–5. doi:10.1006/bbrc.1997.6773. PMID 9223416.

[pmid9409739-6] Csóka AB, Frost GI, Wong T, Stern R, Csóka TB (November 1997). "Purification and microsequencing of hyaluronidase isozymes from human urine". FEBS Letters. 417 (3): 307–10. Bibcode:1997FEBSL.417..307C. doi:10.1016/S0014-5793(97)01309-4. PMID 9409739. S2CID 44929703.

[entrez-7] "Entrez Gene: HYAL1 hyaluronoglucosaminidase 1".

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