HYAL3

HYAL3
Identifiers
Aliases	HYAL3, HYAL-3, LUCA-3, LUCA3, hyaluronoglucosaminidase 3, hyaluronidase 3
External IDs	OMIM: 604038; MGI: 1330288; HomoloGene: 2626; GeneCards: HYAL3; OMA:HYAL3 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	50,299,405 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	107,464,558 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; bone marrow; ; prefrontal cortex; ; left testis; ; right hemisphere of cerebellum; ; right testis; ; superior frontal gyrus; ; primary visual cortex; ; right frontal lobe;
	Top expressed in
	embryo; ; embryo; ; right kidney; ; blastocyst; ; proximal tubule; ; spermatid; ; zygote; ; vestibular membrane of cochlear duct; ; ventricular zone; ; tail of embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity, acting on glycosyl bonds; protein binding; hyaluronoglucuronidase activity; hydrolase activity; catalytic activity; hyalurononglucosaminidase activity;
Cellular component	extracellular region; acrosomal vesicle; acrosomal membrane; lysosome; endosome; early endosome; endoplasmic reticulum; plasma membrane; membrane; cytoplasmic vesicle; sperm midpiece;
Biological process	cellular response to UV-B; cartilage development; response to antibiotic; cellular response to tumor necrosis factor; metabolism; cellular response to interleukin-1; inflammatory response; hyaluronan catabolic process; carbohydrate metabolic process; response to virus; ovarian follicle atresia; single fertilization; penetration of zona pellucida; negative regulation of ovarian follicle development; positive regulation of acrosomal vesicle exocytosis; viral entry into host cell;
	Sources:Amigo / QuickGO
Orthologs
	8372
	109685
	ENSG00000186792
	ENSMUSG00000036091
	O43820
	Q8VEI3
	NM_003549; NM_001200029; NM_001200030; NM_001200031; NM_001200032
	NM_178020
	NP_001186958; NP_001186959; NP_001186960; NP_001186961; NP_003540
	NP_821139
	Wikidata
View/Edit Human	View/Edit Mouse

Hyaluronidase-3 is an enzyme that in humans is encoded by the HYAL3 gene.^[5]^[6]

This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186792 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036091 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Csoka AB, Scherer SW, Stern R (Nov 1999). "Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31". Genomics. 60 (3): 356–61. doi:10.1006/geno.1999.5876. PMID 10493834.
^ ^a ^b "Entrez Gene: HYAL3 hyaluronoglucosaminidase 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186792 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036091 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10493834-5] Csoka AB, Scherer SW, Stern R (Nov 1999). "Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31". Genomics. 60 (3): 356–61. doi:10.1006/geno.1999.5876. PMID 10493834.

[entrez-6] "Entrez Gene: HYAL3 hyaluronoglucosaminidase 3".

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