| Handan Sultan | |
|---|---|
 Tomb of Handan Sultan in Mehmed III's mausoleum | |
| Valide sultan of the Ottoman Empire | |
| Tenure | 22 December 1603 – 9 November 1605 |
| Predecessor | Safiye Sultan |
| Successor | Halime Sultan |
| Born | Helena c. 1568 Bosnia |
| Died | 9 November 1605 (aged c. 36-37) Topkapı Palace, Constantinople, Ottoman Empire |
| Burial | Mehmed III Mausoleum, Hagia Sophia Mosque, Istanbul |
| Consort | Mehmed III |
| Issue | Fatma Sultan Şehzade Selim Şehzade Süleyman Ayşe Sultan Ahmed I Şehzade Osman |
| Religion | Sunni Islam (converted) |
Handan Sultan (Ottoman Turkish: خندان سلطان, "smiling"; c. 1568 - 9 November 1605) was a consort of Ottoman Sultan Mehmed III, and mother and Valide Sultan to their son Sultan Ahmed I.