Haptocorrin

TCN1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4KKI, 4KKJ
Identifiers
Aliases	TCN1, HC, TC-1, TC1, TCI, transcobalamin 1
External IDs	OMIM: 189905; HomoloGene: 47985; GeneCards: TCN1; OMA:TCN1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.1 Start 59,852,800 bp[1] End 59,866,489 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell olfactory zone of nasal mucosa trachea parotid gland gallbladder bone marrow bone marrow cells nasal epithelium trabecular bone testicle n/a More reference expression data BioGPS n/a
Gene ontology Molecular function cobalamin binding Cellular component extracellular region extracellular space specific granule lumen tertiary granule lumen Biological process cobalamin metabolic process cobalt ion transport ion transport cobalamin transport neutrophil degranulation transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6947 n/a Ensembl ENSG00000134827 n/a UniProt P20061 n/a RefSeq (mRNA) NM_001062 n/a RefSeq (protein) NP_001053 n/a Location (UCSC) Chr 11: 59.85 – 59.87 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Haptocorrin (HC) also known as transcobalamin-1 (TC-1) or cobalophilin is a transcobalamin protein that in humans is encoded by the TCN1 gene.^[3] One essential function of haptocorrin is protection of the acid-sensitive vitamin B₁₂ while it moves through the stomach. A second function is serum HC binding of the great majority of circulating vitamin B₁₂, rendering it unavailable for take-up by cells. This is conjectured to be a circulating storage function.