Heisler is a surname. Notable people with the surname include:
- Charlene Heisler (1961–1999), Canadian astronomer
- Charles L. Heisler, American steam locomotive designer
- Conrad Heisler, character in The Angry Hills (film)
- Gregory Heisler (born 1954), American photographer
- Jindřich Heisler, a Czech surrealist poet, friend of Toyen
- L. Heisler Ball (1861–1932), physician and Delaware Senator
- Mark Heisler, a sports writers and author
- Marcy Heisler (born 1967), musical theater writer and performer
- Mike Heisler, American comic book writer
- Todd Heisler (born 1972), American photojournalist
- Randy Heisler (born 1961), American Olympic discus thrower
- Stuart Heisler (1896–1979), film and television director