Helen Smith may refer to:
- Helen Smith (literary scholar), scholar of English literature
- Helen Smith (baseball) (1922–2019), All-American Girls Professional Baseball League player
- Helen Smith (fencer) (born 1953), Australian Olympic fencer
- Helen Smith (nurse) (1956–1979), died in suspicious circumstances in Saudi Arabia
- Helen Smith (psychologist), American forensic psychologist
- Helen Smith (politician) (1927–2007), New Zealand politician in the Values Party
- Helen Smith (writer) (born 1968), English novelist and dramatist
- Helen Douglas Smith (1886–1955), Canadian politician
- Helen Fairchild Smith (died 1926), professor of English literature and Dean of Wells College
- Helen Hay Smith (1873–1918), New Zealand clothing manufacturer and retailer
- Helen Macpherson Smith (1874–1951), Australian philanthropist
- Helen Sobel Smith (1909–1969), American bridge player
- Helen Wong Smith (fl. 1980s–2010s), American archivist and librarian
- Helen Smith, a character in the television series Moonbase 3
- Baby Bunny Smith (1888–1951), sideshow performer born as Helen Smith