Hellenistic Palestine[1][2][3] (320 BCE- 63 BCE) is the term for historic Palestine during the Hellenistic period, when Achaemenid Syria was conquered by Alexander the Great in 333 BCE and subsumed into his growing Macedonian empire. After his death in 323 BCE, Alexander's empire was divided among his generals, the Diadochi, marking the beginning of Macedonian rule over various territories, including Coele-Syria. The region came under Ptolemaic rule beginning when Ptolemy I Soter took control of Egypt in 322 BCE and subsequently Yehud Medinata in 320 BCE due to its strategic significance. This period saw numerous conflicts as former generals vied for control, leading to ongoing power struggles and territorial exchanges.
Ptolemaic rule brought initial stability and economic prosperity to the region. Ptolemy I and his successor, Ptolemy II Philadelphus, maintained control over Yehud Medinata, with the latter bringing the Ptolemaic dynasty to its zenith by winning the first and second Syrian Wars. Despite these successes, ongoing conflicts with the Seleucids, particularly over the strategic region of Coele-Syria, led to more Syrian Wars. The peace and stability enjoyed by the local population under Ptolemaic rule were disrupted by these wars, and the region's control fluctuated due to the military campaigns and political maneuvers.
Seleucid rule began in 198 BCE under Antiochus III the Great, who, like the Ptolemies, allowed the Jews to retain their customs and religion. However, financial strains due to obligations to Rome led to unpopular measures, such as temple robberies, which ultimately resulted in Antiochus III's death in 187 BCE. His successors faced similar challenges, with internal conflicts and external pressures leading to dissatisfaction among the local population. The Maccabean Revolt, led by Judas Maccabeus, highlighted the growing unrest and resistance against Seleucid authority, eventually leading to significant shifts in power dynamics within the region.
The local Hasmonean dynasty emerged from the Maccabean Revolt, with Simon Thassi becoming high priest and ruler, establishing an independent Judea. His successors, notably John Hyrcanus, expanded the kingdom and maintained relations with Rome and Egypt. However, internal strife and external pressures, particularly from the Seleucids and later the Romans, led to the decline of the Hasmonean dynasty. The intervention of the Roman general Pompey in the 63 BCE Siege of Jerusalem, marked the end of independent Hasmonean rule. The region was annexed by the Roman Republic, marking the end of Hellenistic Palestine and the beginning of client Roman Judea. The dynasty's official end came in 40 BCE when Herod the Great was crowned king of Judea by the Romans, solidifying Roman control over the region.