Hemicentin 1

HMCN1
Identifiers
Aliases	HMCN1, ARMD1, FBLN6, FIBL-6, FIBL6, hemicentin 1
External IDs	OMIM: 608548; MGI: 2685047; HomoloGene: 23741; GeneCards: HMCN1; OMA:HMCN1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	186,190,949 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	150,869,186 bp
RNA expression pattern
	Top expressed in
	Descending thoracic aorta; ; ascending aorta; ; visceral pleura; ; right coronary artery; ; skin of hip; ; left coronary artery; ; synovial membrane; ; synovial joint; ; cardiac muscle tissue of right atrium; ; right lung;
	Top expressed in
	hand; ; atrium; ; Gonadal ridge; ; atrioventricular valve; ; external carotid artery; ; vas deferens; ; dermis; ; vestibular membrane of cochlear duct; ; condyle; ; lung;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; extracellular matrix structural constituent; signaling receptor activity; protein homodimerization activity; cell adhesion molecule binding;
Cellular component	extracellular matrix; extracellular region; basement membrane; cell junction; cell cortex; extracellular exosome; cytoplasm; cleavage furrow; collagen-containing extracellular matrix;
Biological process	response to stimulus; visual perception; cell cycle; cell division; homophilic cell adhesion via plasma membrane adhesion molecules; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
	83872
	545370
	ENSG00000143341
	ENSMUSG00000066842
	Q96RW7
	D3YXG0
	NM_031935
	NM_001024720
	NP_114141
	NP_001019891
	Wikidata
View/Edit Human	View/Edit Mouse

Hemicentin-1 is a protein that in humans is encoded by the HMCN1 gene.^[5]^[6]

This gene encodes a large extracellular member of the immunoglobulin superfamily. A similar protein in C. elegans forms long, fine tracks at specific extracellular sites that are involved in many processes such as stabilization of the germline syncytium, anchorage of mechanosensory neurons to the epidermis, and organization of hemidesmosomes in the epidermis. Mutations in this gene may be associated with age-related macular degeneration.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143341 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000066842 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vogel BE, Hedgecock EM (Mar 2001). "Hemicentin, a conserved extracellular member of the immunoglobulin superfamily, organizes epithelial and other cell attachments into oriented line-shaped junctions". Development. 128 (6): 883–94. doi:10.1242/dev.128.6.883. PMID 11222143.
^ ^a ^b "Entrez Gene: HMCN1 hemicentin 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143341 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000066842 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11222143-5] Vogel BE, Hedgecock EM (Mar 2001). "Hemicentin, a conserved extracellular member of the immunoglobulin superfamily, organizes epithelial and other cell attachments into oriented line-shaped junctions". Development. 128 (6): 883–94. doi:10.1242/dev.128.6.883. PMID 11222143.

[entrez-6] "Entrez Gene: HMCN1 hemicentin 1".

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