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| Henri I de Lorraine | |
|---|---|
 | |
| Duke of Guise | |
| Reign | 24 February 1563 – 23 December 1588 |
| Predecessor | François |
| Successor | Charles |
| Born | 31 December 1550 |
| Died | 23 December 1588 (aged 37) Château de Blois, Blois, France |
| Spouse | Catherine of Cleves |
| Issue among others... | |
| House | Guise |
| Father | François, Duke of Guise |
| Mother | Anna d'Este |
| Religion | Catholicism |
| Signature |  |
Henri I de Lorraine, Duke of Guise, Prince of Joinville, Count of Eu (31 December 1550 – 23 December 1588), sometimes called Le Balafré ('Scarface'), was the eldest son of François, Duke of Guise, and Anna d'Este. His maternal grandparents were Ercole II d'Este, Duke of Ferrara, and Renée of France. Through his maternal grandfather, he was a descendant of Lucrezia Borgia and Pope Alexander VI.
A key figure in the French Wars of Religion, he was one of the namesakes of the War of the Three Henrys. A powerful opponent of the queen mother, Catherine de' Medici, Henri was assassinated by the bodyguards of her son, King Henry III.