Hepatocyte growth factor

HGF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BHT, 1GMN, 1GMO, 1GP9, 1NK1, 1SHY, 1SI5, 2HGF, 2QJ2, 3HMS, 3HMT, 3HN4, 3MKP, 3SP8, 4K3J, 4O3T, 4O3U, 5COE, 5CP9, 5CS1, 5CS3, 5CS5, 5CS9, 5CSQ, 5CT1, 5CT2, 5CT3, 4D3C
Identifiers
Aliases	HGF, DFNB39, F-TCF, HGFB, HPTA, SF, hepatocyte growth factor
External IDs	OMIM: 142409; MGI: 96079; HomoloGene: 503; GeneCards: HGF; OMA:HGF - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.11 Start 81,699,010 bp[1] End 81,770,438 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 A3|5 7.07 cM Start 16,758,493 bp[2] End 16,825,150 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta stromal cell of endometrium visceral pleura buccal mucosa cell monocyte pancreatic epithelial cell gallbladder Epithelium of choroid plexus liver right coronary artery Top expressed in lumbar spinal ganglion granulocyte urethra stria vascularis genital tubercle embryo primitive endoderm pineal gland abdominal wall right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding chemoattractant activity protein heterodimerization activity growth factor activity serine-type endopeptidase activity protein tyrosine kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component membrane extracellular region platelet alpha granule lumen extracellular space Biological process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of hydrogen peroxide-mediated programmed cell death positive regulation of neuron projection regeneration positive regulation of interleukin-10 production positive regulation of cell migration cellular response to hepatocyte growth factor stimulus negative regulation of release of cytochrome c from mitochondria negative regulation of interleukin-6 production platelet degranulation negative regulation of apoptotic process regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling positive regulation of angiogenesis positive regulation of myelination positive regulation of osteoblast differentiation myoblast proliferation negative regulation of extrinsic apoptotic signaling pathway via death domain receptors animal organ regeneration cell morphogenesis positive regulation of cell population proliferation hyaluronan metabolic process positive regulation of DNA biosynthetic process negative regulation of peptidyl-serine phosphorylation epithelial to mesenchymal transition positive regulation of peptidyl-tyrosine phosphorylation cell chemotaxis liver development positive regulation of phosphatidylinositol 3-kinase signaling regulation of p38MAPK cascade cell population proliferation negative regulation of autophagy hepatocyte growth factor receptor signaling pathway negative regulation of inflammatory response positive regulation of transcription by RNA polymerase II regulation of tau-protein kinase activity proteolysis positive chemotaxis MAPK cascade peptidyl-tyrosine phosphorylation phosphatidylinositol phosphate biosynthetic process mitotic cell cycle regulation of signaling receptor activity positive regulation of protein kinase B signaling positive regulation of protein phosphorylation cytokine-mediated signaling pathway epithelial cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3082 15234 Ensembl ENSG00000019991 ENSMUSG00000028864 UniProt P14210 Q08048 RefSeq (mRNA) NM_000601 NM_001010931 NM_001010932 NM_001010933 NM_001010934 NM_010427 NM_001289458 NM_001289459 NM_001289460 NM_001289461 RefSeq (protein) NP_000592 NP_001010931 NP_001010932 NP_001010933 NP_001010934 NP_001276387 NP_001276388 NP_001276389 NP_001276390 NP_034557 Location (UCSC) Chr 7: 81.7 – 81.77 Mb Chr 5: 16.76 – 16.83 Mb PubMed search [3] [4]
Wikidata
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Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells and T cells. It has been shown to have a major role in embryonic organ development, specifically in myogenesis, in adult organ regeneration, and in wound healing.^[5]