Hepcidin

HAMP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M4E, 1M4F, 2KEF, 3H0T, 4QAE
Identifiers
Aliases	HAMP, HEPC, HFE2B, LEAP1, PLTR, hepcidin antimicrobial peptide
External IDs	OMIM: 606464; MGI: 2153530; HomoloGene: 81623; GeneCards: HAMP; OMA:HAMP - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.12 Start 35,280,716 bp[1] End 35,285,143 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B1|7 19.27 cM Start 30,621,797 bp[2] End 30,624,106 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver right auricle cardiac muscle tissue of right atrium C1 segment optic nerve caput epididymis body of pancreas pancreatic ductal cell internal globus pallidus Skeletal muscle tissue of rectus abdominis Top expressed in epithelium of stomach left lobe of liver mucous cell of stomach pyloric antrum islet of Langerhans secondary oocyte zygote skin of back primary oocyte thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hormone activity iron ion transmembrane transporter inhibitor activity signaling receptor binding Cellular component cytoplasm extracellular region apical cortex intercalated disc extracellular space Biological process negative regulation of iron export across plasma membrane negative regulation of intestinal absorption positive regulation of receptor internalization negative regulation of transcription by RNA polymerase II negative regulation of iron ion transmembrane transporter activity response to iron ion multicellular organismal iron ion homeostasis defense response to bacterium immune response positive regulation of receptor catabolic process positive regulation of protein polyubiquitination negative regulation of ion transmembrane transporter activity cellular iron ion homeostasis cellular response to lipopolysaccharide human ageing cellular response to tumor necrosis factor liver regeneration cellular response to bile acid cellular response to interleukin-6 response to iron ion starvation response to vitamin A response to erythropoietin positive regulation of cell growth involved in cardiac muscle cell development response to ethanol acute-phase response cellular response to X-ray response to zinc ion negative regulation of iron ion transmembrane transport antimicrobial humoral immune response mediated by antimicrobial peptide killing of cells of other organism defense response to fungus regulation of signaling receptor activity signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57817 66438 Ensembl ENSG00000105697 ENSMUSG00000056978 UniProt P81172 Q80T19 RefSeq (mRNA) NM_021175 NM_183257 RefSeq (protein) NP_066998 NP_899080 Location (UCSC) Chr 19: 35.28 – 35.29 Mb Chr 7: 30.62 – 30.62 Mb PubMed search [3] [4]
Wikidata
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Hepcidin
Solution structure of hepcidin-25.[5]
Identifiers
Symbol	Hepcidin
Pfam	PF06446
InterPro	IPR010500
SCOP2	1m4f / SCOPe / SUPFAM
OPM superfamily	153
OPM protein	1m4e
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Hepcidin is a protein that in humans is encoded by the HAMP gene. Hepcidin is a key regulator of the entry of iron into the circulation in mammals.^[6]

During conditions in which the hepcidin level is abnormally high, such as inflammation, serum iron falls due to iron trapping within macrophages and liver cells and decreased gut iron absorption. This typically leads to anemia due to an inadequate amount of serum iron being available for developing red blood cells. When the hepcidin level is abnormally low such as in hemochromatosis, iron overload occurs due to increased ferroportin mediated iron efflux from storage and increased gut iron absorption.