| β-N-Acetylhexosaminidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
.jpg) Hexosaminidase A (Hex A) | |||||||||
| Identifiers | |||||||||
| EC no. | 3.2.1.52 | ||||||||
| CAS no. | 9012-33-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Hexosaminidase (EC 3.2.1.52, β-acetylaminodeoxyhexosidase, N-acetyl-β-D-hexosaminidase, N-acetyl-β-hexosaminidase, N-acetyl hexosaminidase, β-hexosaminidase, β-acetylhexosaminidinase, β-D-N-acetylhexosaminidase, β-N-acetyl-D-hexosaminidase, β-N-acetylglucosaminidase, hexosaminidase A, N-acetylhexosaminidase, β-D-hexosaminidase) is an enzyme involved in the hydrolysis of terminal N-acetyl-D-hexosamine residues in N-acetyl-β-D-hexosaminides.[1][2][3][4]
Elevated levels of hexosaminidase in blood and/or urine have been proposed as a biomarker of relapse in the treatment of alcoholism.[5]
Hereditary inability to form functional hexosaminidase enzymes are the cause of lipid storage disorders Tay-Sachs disease and Sandhoff disease.[6]
- ^ Cabezas JA (August 1989). "Some comments on the type references of the official nomenclature (IUB) for β-N-acetylglucosaminidase, β-N-acetylhexosaminidase and β-N-acetylgalactosaminidase". Biochem. J. 261 (3): 1059–60. doi:10.1042/bj2611059b. PMC 1138940. PMID 2529847.
- ^ Calvo P, Reglero A, Cabezas JA (November 1978). "Purification and properties of β-N-acetylhexosaminidase from the mollusc Helicella ericetorum Müller". Biochem. J. 175 (2): 743–50. doi:10.1042/bj1750743. PMC 1186125. PMID 33660.
- ^ Frohwein YZ, Gatt S (September 1967). "Isolation of β-N-acetylhexosaminidase, β-N-acetylglucosaminidase, and β-N-acetylgalactosaminidase from calf brain". Biochemistry. 6 (9): 2775–82. doi:10.1021/bi00861a018. PMID 6055190.
- ^ Li SC, Li YT (October 1970). "Studies on the glycosidases of jack bean meal. 3. Crystallization and properties of β-N-acetylhexosaminidase". J. Biol. Chem. 245 (19): 5153–60. doi:10.1016/S0021-9258(18)62830-3. PMID 5506280.
- ^ Allen JP, Sillanaukee P, Strid N, Litten RZ (August 2004). "Biomarkers of Heavy Drinking". National Institute on Alcohol Abuse and Alcoholism. Retrieved 2021-07-11.
- ^ Demczko, Matt. "Tay-Sachs Disease and Sandhoff Disease". MSD Manual.