Histone deacetylase 5

HDAC5
Identifiers
Aliases	HDAC5, HD5, NY-CO-9, histone deacetylase 5
External IDs	OMIM: 605315; MGI: 1333784; HomoloGene: 3995; GeneCards: HDAC5; OMA:HDAC5 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	44,123,702 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	102,230,166 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; skin of abdomen; ; ganglionic eminence; ; muscle of thigh; ; right frontal lobe; ; popliteal artery; ; tibial arteries; ; right hemisphere of cerebellum; ; apex of heart; ; gastric mucosa;
	Top expressed in
	neural layer of retina; ; perirhinal cortex; ; entorhinal cortex; ; CA3 field; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; lip; ; muscle of thigh; ; central gray substance of midbrain;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	NAD-dependent histone deacetylase activity (H3-K14 specific); protein deacetylase activity; histone deacetylase binding; chromatin binding; metal ion binding; protein binding; hydrolase activity; protein kinase C binding; histone deacetylase activity; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	Golgi apparatus; histone deacetylase complex; cytoplasm; nucleus; nucleoplasm; cytosol; nuclear speck; protein-containing complex;
Biological process	histone H3 deacetylation; chromatin remodeling; regulation of myotube differentiation; regulation of transcription, DNA-templated; regulation of gene expression, epigenetic; positive regulation of DNA-binding transcription factor activity; regulation of histone H3-K9 acetylation; response to activity; transcription, DNA-templated; protein deacetylation; negative regulation of cell migration involved in sprouting angiogenesis; B cell activation; neuron differentiation; negative regulation of myotube differentiation; cellular response to insulin stimulus; B cell differentiation; inflammatory response; regulation of protein binding; negative regulation of transcription, DNA-templated; cellular response to lipopolysaccharide; positive regulation of transcription by RNA polymerase II; response to cocaine; negative regulation of transcription by RNA polymerase II; histone deacetylation; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	10014
	15184
	ENSG00000108840
	ENSMUSG00000008855
	Q9UQL6
	Q9Z2V6
	NM_001015053; NM_005474; NM_139205; NM_001382393
NM_001077696; NM_001284248; NM_001284249; NM_001284250; NM_010412;
	NM_001361596
	NP_001015053; NP_005465; NP_001369322
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Histone deacetylase 5 is an enzyme that in humans is encoded by the HDAC5 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108840 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000008855 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Grozinger CM, Hassig CA, Schreiber SL (April 1999). "Three proteins define a class of human histone deacetylases related to yeast Hda1p". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 4868–73. Bibcode:1999PNAS...96.4868G. doi:10.1073/pnas.96.9.4868. PMC 21783. PMID 10220385.
^ Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, et al. (May 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". International Journal of Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721. S2CID 916155.
^ "Entrez Gene: HDAC5 histone deacetylase 5".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108840 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000008855 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10220385-5] Grozinger CM, Hassig CA, Schreiber SL (April 1999). "Three proteins define a class of human histone deacetylases related to yeast Hda1p". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 4868–73. Bibcode:1999PNAS...96.4868G. doi:10.1073/pnas.96.9.4868. PMC 21783. PMID 10220385.

[pmid9610721-6] Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, et al. (May 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". International Journal of Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721. S2CID 916155.

[entrez-7] "Entrez Gene: HDAC5 histone deacetylase 5".

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