| Holby City | |
|---|---|
| Series 20 | |
 The Series 20 Cast Image | |
| No. of episodes | 52 |
| Release | |
| Original network | BBC One BBC One HD |
| Original release | 2 January – 27 December 2018 |
| Series chronology | |
The twentieth series of the British medical drama television series Holby City began airing on BBC One in the United Kingdom on 2 January 2018, and concluded on 27 December 2018. The series consists of 52 episodes; a decrease from the previous series. Kate Hall serves as the series producer, while Simon Harper continued his role as the executive producer. Fifteen cast members reprised their roles from the previous series. Four actors departed during the series, including long-standing cast member James Anderson (Oliver Valentine). Catherine Russell reprised her role as Serena Campbell from episode six. Throughout the series, multiple characters returned for guest stints, including Zosia March (Camilla Arfwedson), Bernie Wolfe (Jemma Redgrave) and Mo Effanga (Chizzy Akudolu).