Homeobox protein CDX-2 is a protein that in humans is encoded by the CDX2 gene. The CDX-2 protein is a homeobox transcription factor expressed in the nuclei of intestinal epithelial cells,[5][6] playing an essential role in the development and function of the digestive system. CDX2 is part of the ParaHox gene cluster, a group of three highly conserved developmental genes present in most vertebrate species.[7] Together with CDX1 and CDX4, CDX2 is one of three caudal-related genes in the human genome.
- ^ a b c GRCh38: Ensembl release 89: ENSG00000165556 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029646 – Ensembl, May 2017
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- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ German MS, Wang J, Fernald AA, Espinosa R, Le Beau MM, Bell GI (November 1994). "Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13". Genomics. 24 (2): 403–404. doi:10.1006/geno.1994.1639. PMID 7698771.
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:0was invoked but never defined (see the help page). - ^ Brooke NM, Garcia-Fernàndez J, Holland PW (April 1998). "The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster". Nature. 392 (6679): 920–922. Bibcode:1998Natur.392..920B. doi:10.1038/31933. PMID 9582071. S2CID 4398740.