Homeobox protein CDX-4

CDX4
Identifiers
Aliases	CDX4, caudal type homeobox 4
External IDs	OMIM: 300025; MGI: 88362; HomoloGene: 3806; GeneCards: CDX4; OMA:CDX4 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq13.2 Start 73,447,053 bp[1] End 73,455,171 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X D|X 46.06 cM Start 102,365,004 bp[2] End 102,374,198 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen gonad embryo skin of limb skin of leg nervous system tibial nerve Top expressed in tail of embryo embryo urethra male urethra primitive streak embryo blastocyst allantois right kidney proximal tubule More reference expression data BioGPS n/a
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity Cellular component nucleus Biological process animal organ morphogenesis multicellular organism development labyrinthine layer development cell differentiation blood vessel development anterior/posterior axis specification regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated positive regulation of transcription by RNA polymerase II anterior/posterior pattern specification placenta development transcription by RNA polymerase II regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1046 12592 Ensembl ENSG00000131264 ENSMUSG00000031326 UniProt O14627 Q07424 RefSeq (mRNA) NM_005193 NM_007674 RefSeq (protein) NP_005184 NP_031700 Location (UCSC) Chr X: 73.45 – 73.46 Mb Chr X: 102.37 – 102.37 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein CDX-4 is a protein that in humans is encoded by the CDX4 gene. This gene is a member of the caudal-related homeobox transcription factor family that also includes CDX1 and CDX2.^[5]